3-[6-(5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-6-[(2-oxopyirolidin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-2-yl)pyridin-3-yl]propanoic acid | 1616278-83-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[6-(5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-6-[(2-oxopyirolidin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-2-yl)pyridin-3-yl]propanoic acid
• 英文别名: 3-[6-[5-(6-methylsulfonylpyridin-3-yl)oxy-6-[(2-oxopyrrolidin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-2-yl]pyridin-3-yl]propanoic acid
• CAS: 1616278-83-1
• 化学式: C₂₆H₂₅N₅O₆S
• 分子量: 535.58
• InChiKey: LXDIYUQRDSIZEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  164
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] NOVEL GLUCOKINASE ACTIVATOR COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT<br/>[FR] NOUVEAUX COMPOSÉS ACTIVATEURS DE GLUCOKINASE, COMPOSITIONS CONTENANT DE TELS COMPOSÉS, ET MÉTHODES DE TRAITEMENT
  申请人：MERCK SHARP & DOHME

  公开号：WO2014099578A1

  公开（公告）日：2014-06-26

  Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.

  公开了式I的新型吡啶-2-羧酰胺衍生物及其药用盐，用于治疗或预防2型糖尿病和类似疾病。这些化合物作为葡萄糖激酶激活剂具有有效性。同时还包括药物组合物和治疗方法。
• NOVEL GLUCOKINASE ACTIVATOR COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT
  申请人：PARMEE Emma R.

  公开号：US20150336991A1

  公开（公告）日：2015-11-26

  Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.

  本发明公开了式I的新型吡啶-2-羧酰胺衍生物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。这些化合物作为葡萄糖激酶激活剂具有良好的治疗效果。此外，本发明还包括药物组合物和治疗方法。
• US9453038B2
  申请人：——

  公开号：US9453038B2

  公开（公告）日：2016-09-27