rac-(3aR,7aS)-2-[(tert-butoxy)carbonyl]-octahydro-1H-isoindole-1-carboxylic acid | 2307710-65-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: rac-(3aR,7aS)-2-[(tert-butoxy)carbonyl]-octahydro-1H-isoindole-1-carboxylic acid
• 英文别名: (3aR,7aS)-2-[(2-methylpropan-2-yl)oxycarbonyl]-1,3,3a,4,5,6,7,7a-octahydroisoindole-1-carboxylic acid
• CAS: 2307710-65-0
• 化学式: C₁₄H₂₃NO₄
• 分子量: 269.34
• InChiKey: AIBSQHAPZPSICF-QRHSGQBVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] CHANGE INHIBITORS OF DIPEPTIDYL PEPTIDASE IV<br/>[FR] CHANGEMENT D'INHIBITEURS DE LA DIPEPTIDYL PEPTIDASE IV
  申请人：GUILFORD PHARMACEUTICALS

  公开号：WO2003057144A2

  公开（公告）日：2003-07-17

  Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.