6-(4-phenyl-1H-1,2,3-triazol-1-yl)-6,7-dihydro-4H-[1,2,3]triazolo-[5,1-c][1,4]oxazine | 1612222-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-(4-phenyl-1H-1,2,3-triazol-1-yl)-6,7-dihydro-4H-[1,2,3]triazolo-[5,1-c][1,4]oxazine
• CAS: 1612222-62-4
• 化学式: C₁₄H₁₄N₆O
• 分子量: 282.305
• InChiKey: GGSWGIAYMSWTTF-UHFFFAOYSA-N

物化性质

• 沸点：
  562.9±60.0 °C(predicted)
• 密度：
  1.47±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  苯乙炔 在 sodium azide 、 Cu*O₄S^(2-)*5H₂O 、 sodium hydride 、 sodium ascorbate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.33h， 生成 6-(4-phenyl-1H-1,2,3-triazol-1-yl)-6,7-dihydro-4H-[1,2,3]triazolo-[5,1-c][1,4]oxazine
  参考文献：
  名称：

  Click Chemistry Inspired Synthesis of Morpholine-Fused Triazoles

  摘要：

  The synthesis of triazolyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by click reaction with alkynes, and subsequent azidation of chlorohydroxy triazoles was achieved under a one-pot methodology. The developed triazolyl azido alcohols were further utilized for the synthesis of a diverse range of morpholine-fused triazoles of chemotherapeutic value. The structure of all developed compounds has been elucidated using IR. NMR, MS, and elemental analysis, where four of them have been characterized by single-crystal X-ray analysis.

  DOI：

  10.1021/jo500890w