1-cyclohexylamino-1-deoxy-D-glucitol | 3797-21-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-cyclohexylamino-1-deoxy-D-glucitol
• 英文别名: 6-Cyclohexylamino-L-gulo-hexanpentol-(1.2.3.4.5)；1-Cyclohexylamino-1-desoxy-D-glucit；N-Cyclohexyl-D-glucamin；N-cyclohexyl-D-glucamine；(2R,3R,4R,5S)-6-(cyclohexylamino)hexane-1,2,3,4,5-pentol
• CAS: 3797-21-5
• 化学式: C₁₂H₂₅NO₅
• 分子量: 263.334
• InChiKey: GXDKMPKEMFWETC-IRCOFANPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 镍 作用下， 70.0~83.0 ℃ 、8.83 MPa 条件下， 生成 1-cyclohexylamino-1-deoxy-D-glucitol
  参考文献：
  名称：

  The Reaction of Glucose with Some Amines

  摘要：

  DOI：

  10.1021/ja01231a055

文献信息

• Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
  申请人：Syntex Corporation

  公开号：US04246193A1

  公开（公告）日：1981-01-20

  Mixtures of d 2-(6-methoxy-2-naphthyl)propionic acid and 1 2-(6-methoxy-2-naphthyl)propionic acid or soluble salts thereof are resolved with N-R-D-glucamine or salts thereof, where R is alkyl having 2 to 36 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, to yield a product substantially enriched in d 2-(6-methoxy-2-naphthyl)-propionic acid.

  混合物由d 2-(6-甲氧基-2-萘基)丙酸和1 2-(6-甲氧基-2-萘基)丙酸或其可溶性盐组成，这些混合物可用N-R-D-葡萄糖胺或其盐进行分离，其中R是具有2至36个碳原子的烷基或具有3至8个碳原子的环烷基，以产生在d 2-(6-甲氧基-2-萘基)-丙酸方面富集的产物。
• Process for the resolution of d,l 2-(6-methoxy-2-naphthyl)propionic acid; a mixture of the salts of these d and l acids; a pharmaceutical composition containing a salt of the d acid; a salt of the d acid
  申请人：SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

  公开号：EP0022529A1

  公开（公告）日：1981-01-21

  Mixtures of d and 1 2-(6-methoxy-2-naphthyl)propionic acids or soluble salts thereof are resolved with N-R-D-glucamine or salts thereof, where R is alkyl having 2 to 36 carbon atoms or cycloalkyl having 3 to 8 carbon atoms, to yield a product substantially enriched in d 2-(6-methoxy-2--naphthyl)propionic acid; a mixture of the salts of d and 1 2-(6-methoxy-2-naphthyl)propionic acid with N-R-D-glucamine; a salt of d 2-(6-methoxy-2-naphthyl)propionic acid with N-R-D-glucamine and a pharmaceutical composition containing this salt in a pharmaceutically effective amount.

  d和1 2-(6-甲氧基-2-萘基)丙酸或其可溶性盐的混合物与N-R-D-葡糖胺或其盐(其中R为具有2至36个碳原子的烷基或具有3至8个碳原子的环烷基)进行解析，得到一种d 2-(6-甲氧基-2-萘基)丙酸含量相当丰富的产物；d 2-(6-甲氧基-2-萘基)丙酸和 1 2-(6-甲氧基-2-萘基)丙酸与 N-R-D-氨基葡萄糖的盐的混合物；d 2-(6-甲氧基-2-萘基)丙酸和 N-R-D-氨基葡萄糖的盐，以及含有该盐的药用有效量的药物组合物。
• Process for the preparation of (d) 2-(d-methoxy-2-naphthyl) propionic acid and pharmaceutically acceptable salts thereof and new intermediates therefor
  申请人：SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

  公开号：EP0095901B1

  公开（公告）日：1992-09-09
• US4246193A
  申请人：——

  公开号：US4246193A

  公开（公告）日：1981-01-20
• US4395571A
  申请人：——

  公开号：US4395571A

  公开（公告）日：1983-07-26