5-[5-(2,2-difluoro-[1,3]dioxolo[4,5-g]quinolin-8-yloxy)-pyridin-2-yl]-2-(2-fluoro-phenylamino)-3-methyl-3H-pyrimidin-4-one | 1355620-72-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-[5-(2,2-difluoro-[1,3]dioxolo[4,5-g]quinolin-8-yloxy)-pyridin-2-yl]-2-(2-fluoro-phenylamino)-3-methyl-3H-pyrimidin-4-one
• 英文别名: 5-[5-[(2,2-Difluoro-[1,3]dioxolo[4,5-g]quinolin-8-yl)oxy]pyridin-2-yl]-2-(2-fluoroanilino)-3-methylpyrimidin-4-one
• CAS: 1355620-72-2
• 化学式: C₂₆H₁₆F₃N₅O₄
• 分子量: 519.439
• InChiKey: DDZLMFGBCRSSMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS HÉTÉROCYCLIQUES FUSIONNÉS CONVENANT COMME INHIBITEURS DE C-MET TYROSINE KINASE
  申请人：ZHEJIANG BETA PHARMA INC

  公开号：WO2012006960A1

  公开（公告）日：2012-01-19

  Certain novel fused quinazoline derivatives of formula (I) as c-Met inhibitors, their synthesis and their uses for treating a c-Met mediated disorder. Methods for treating a c-Met-mediated disorder are also disclosed in the invention.

  某些新型融合喹唑啉衍生物的化学式（I），作为c-Met抑制剂，它们的合成以及用于治疗c-Met介导的疾病的用途。该发明还揭示了治疗c-Met介导疾病的方法。
• Novel Fused Heterocyclic Derivatives Useful as c-Met Tyrosine Kinase Inhibitors
  申请人：Hu Shaojing

  公开号：US20130123286A1

  公开（公告）日：2013-05-16

  Certain novel fused quinazoline derivatives of formula (I) as c-Met inhibitors, their synthesis and their uses for treating a c-Met mediated disorder. Methods for treating a c-Met-mediated disorder are also disclosed in the invention.

  某些新型融合喹唑啉衍生物（化学式（I））作为c-Met抑制剂，它们的合成以及用于治疗c-Met介导的疾病的用途。该发明还公开了治疗c-Met介导的疾病的方法。
• NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS
  申请人：Zhejiang Beta Pharma Inc.

  公开号：EP2593462A1

  公开（公告）日：2013-05-22
• NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS
  申请人：Betta Pharmaceuticals Co., Ltd.

  公开号：EP2593462B1

  公开（公告）日：2016-09-07
• US9242991B2
  申请人：——

  公开号：US9242991B2

  公开（公告）日：2016-01-26