1-N--β-D-glucopyranosylamine | 73348-35-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 1-N--β-D-glucopyranosylamine
• CAS: 73348-35-3
• 化学式: C₄₅H₅₈N₈O₁₂
• 分子量: 903.002
• InChiKey: WKPSODFIUCEXRN-KQLZMBAUSA-N

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 1-N--β-D-glucopyranosylamine 、 碘甲烷 在 乙酸酐-d6 、 dimsylsodium 作用下， 生成
  参考文献：
  名称：

  Solid-phase synthesis of two glycopeptides containing the amino acid sequence 5 to 9 of somatostatin

  摘要：

  2,3,4,6-Tetra-O-acetyl-1-N-[N-(tert-butyloxycarbonyl)-L-aspart-4-oyl]-D-g lucopyranosylamine and 2-acetamido-3,4,6-tri-O-acetyl-1-N-[N-(tert-butyloxycarbonyl)-L-aspart-4-oyl]-2 -deoxy-D-glucopyranosylamine were introduced, respectively, by the solid-phase procedure in the amino acid sequence 5 to 9 of somatostatin. The two resulting glycopeptides beta-D-Glcp-(1 leads to 4)- and beta-D-GlcpNAc-(1 leads to 4)-Asn-Phe-Phe-Trp-Lys-OH were homogeneous on examination by t.l.c. and l.c., and their structures were confirmed by m.s. of the N-acetyl, permethyl derivatives.

  DOI：

  10.1016/s0008-6215(00)85247-7
• 作为产物：
  描述：

  (S)-6-Amino-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-amino-3-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-ylcarbamoyl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 在 氨 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以123 mg的产率得到1-N--β-D-glucopyranosylamine
  参考文献：
  名称：

  Solid-phase synthesis of two glycopeptides containing the amino acid sequence 5 to 9 of somatostatin

  摘要：

  2,3,4,6-Tetra-O-acetyl-1-N-[N-(tert-butyloxycarbonyl)-L-aspart-4-oyl]-D-g lucopyranosylamine and 2-acetamido-3,4,6-tri-O-acetyl-1-N-[N-(tert-butyloxycarbonyl)-L-aspart-4-oyl]-2 -deoxy-D-glucopyranosylamine were introduced, respectively, by the solid-phase procedure in the amino acid sequence 5 to 9 of somatostatin. The two resulting glycopeptides beta-D-Glcp-(1 leads to 4)- and beta-D-GlcpNAc-(1 leads to 4)-Asn-Phe-Phe-Trp-Lys-OH were homogeneous on examination by t.l.c. and l.c., and their structures were confirmed by m.s. of the N-acetyl, permethyl derivatives.

  DOI：

  10.1016/s0008-6215(00)85247-7