1-azidoicosane | 935676-78-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-azidoicosane
• CAS: 935676-78-1
• 化学式: C₂₀H₄₁N₃
• 分子量: 323.566
• InChiKey: FCTFJEKQGPMCCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-azidoicosane 在 palladium on activated charcoal 氢气 作用下， 以 正己烷 为溶剂， 20.0 ℃ 、427.48 kPa 条件下， 反应 3.0h， 以75%的产率得到二十胺
  参考文献：
  名称：

  Synthesis, Critical Micelle Concentrations, and Antimycobacterial Properties of Homologous, Dendritic Amphiphiles. Probing Intrinsic Activity and the “Cutoff” Effect

  摘要：

  Newkome-type, 1 -> 3 C-branched dendrons make an excellent headgroup for amphiphiles with ultralong, saturated, linear alkyl chains. Synthesis of a homologous series of five such amphiphiles from 14 to 22 carbonsRNHCONHC(CH2CH2CO2H)(3), R = n-CnH2n+1, n = 14, 16, 18, 20, 22proceeds readily. These amphiphiles are soluble in aqueous solutions of triethanolamine. Surface-tension measurements on this homologous series reveal an unusually gradual decrease in log critical micelle concentration (CMC) as the chain length increases. In fact, the tetradecyl homologue does not appear to form micelles. Further, measurements of minimal inhibitory concentration (MIC) by broth microdilution against Mycobacterium smegmatis as a function of the initial cell density provide a direct measure of the intrinsic activity (MIC0) of each homologue. The hexadecyl homologue is the most active at inhibiting growth with an MIC0 equal to 3.5 x 10(-5) M, which is 100-fold below the CMC.

  DOI：

  10.1021/jm061240d
• 作为产物：
  描述：

  icosyl mesylate 在 sodium azide 、 十六烷基三甲基溴化铵 、 lithium bromide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 86.0h， 生成 1-azidoicosane
  参考文献：
  名称：

  Synthesis, Critical Micelle Concentrations, and Antimycobacterial Properties of Homologous, Dendritic Amphiphiles. Probing Intrinsic Activity and the “Cutoff” Effect

  摘要：

  Newkome-type, 1 -> 3 C-branched dendrons make an excellent headgroup for amphiphiles with ultralong, saturated, linear alkyl chains. Synthesis of a homologous series of five such amphiphiles from 14 to 22 carbonsRNHCONHC(CH2CH2CO2H)(3), R = n-CnH2n+1, n = 14, 16, 18, 20, 22proceeds readily. These amphiphiles are soluble in aqueous solutions of triethanolamine. Surface-tension measurements on this homologous series reveal an unusually gradual decrease in log critical micelle concentration (CMC) as the chain length increases. In fact, the tetradecyl homologue does not appear to form micelles. Further, measurements of minimal inhibitory concentration (MIC) by broth microdilution against Mycobacterium smegmatis as a function of the initial cell density provide a direct measure of the intrinsic activity (MIC0) of each homologue. The hexadecyl homologue is the most active at inhibiting growth with an MIC0 equal to 3.5 x 10(-5) M, which is 100-fold below the CMC.

  DOI：

  10.1021/jm061240d

文献信息

• Nanostructuring of Bridged Organosilane Precursors with Pendant Alkyl Chains
  作者：Sílvia C. Nunes、Kristýna Bürglová、Jana Hodačová、Rute A. S. Ferreira、Luís D. Carlos、Paulo Almeida、Xavier Cattoën、Michel Wong Chi Man、Verónica de Zea Bermudez

  DOI：10.1002/ejic.201402673

  日期：2015.3

  copper-catalyzed alkyne azide cycloaddition (CuAAC) reaction was combined with sol-gel reactions for the production of bridged silsesquioxanes (BSs) in which hexyl and icosanyl chains are pendant and anchored on a single position to a triazole ring. The influence of the alkyl chain length on the structure of the BSs, represented by the notation Cn/siloxane (where n = 6 and 20), was examined. The C20/siloxane

  铜催化的炔烃叠氮化物环加成 (CuAAC) 反应与溶胶-凝胶反应相结合，用于生产桥连倍半硅氧烷 (BS)，其中己基和二十烷基链悬垂并锚定在三唑环的单个位置上。检查了烷基链长度对 BS 结构的影响，由符号 Cn/硅氧烷（其中 n = 6 和 20）表示。C20/硅氧烷杂化物是一种疏水材料，具有分层结构的层状双层组织、由纳米厚度的微板组成的纹理和可逆的与时间无关的有序/无序相变（在 60°C 开始）。自组装的驱动力是二十烷基链之间的范德华相互作用和三唑环之间的 π-π 相互作用。在基本上无定形的 C6/硅氧烷杂化物中，
• Coordination-Induced Multivalent Self-Assembling Catalysts for Spectral Sensing Zn²⁺ with High Selectivity and Sensitivity
  作者：Shuai-Bing Li、Jiang-Shan Shen

  DOI：10.1021/acs.inorgchem.3c00545

  日期：2023.6.19

  The introduction of signal amplification to molecular spectral sensing systems is an intriguing topic in supramolecular analytical chemistry. In this study, click chemistry was used to generate a triazole moiety to bridge with a long hydrophobic alkyl chain (Cn) and another short alkyl chain (Cm) bearing a 1,4,7-triazacyclonane (TACN) group for efficiently generating a self-assembling multivalent catalyst

  将信号放大引入分子光谱传感系统是超分子分析化学中一个有趣的话题。在这项研究中，点击化学用于生成三唑部分，以与长疏水烷基链 (C n ) 和另一个带有 1,4,7-三氮杂环烷 (TACN) 基团的短烷基链 (C m ) 桥接，以有效生成自组装多价催化剂，C n -三唑-C m -TACN·Zn 2+（n和m分别代表两个烷基链的碳数；n = 16、18和20；m= 2 和 6), 当加入Zn 2+时催化磷酸 2-羟丙基-4-硝基苯酯 (HPNPP) 的水解。在TACN基团附近引入的三唑部分在提高Zn 2+的选择性方面起着重要作用，因为三唑部分可以参与Zn 2+与相邻TACN基团之间的配位相互作用。辅助三唑络合增加了配位金属离子的空间需求。这种催化传感系统还显示出高灵敏度，具有低至 350 nM 的有利检测限，即使仅使用紫外 - 可见吸收光谱而不是更灵敏的荧光技术进行信号传递，并且可用于确定 Zn
• METHODS FOR MODULATING IKS CHANNEL ACTIVITY
  申请人：ELINDER Fredrik

  公开号：US20170216240A1

  公开（公告）日：2017-08-03

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate I ks channels to treat conditions associated with a disruption in I ks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pK a values, which can activate (i.e., open) I Ks channels, and positively charged PUFAs that can inhibit (i.e., close) I KS channels.
• [EN] METHODS FOR MODULATING IKS CHANNEL ACTIVITY<br/>[FR] PROCÉDÉS PERMETTANT DE MODULER L'ACTIVITÉ DES CANAUX IKS
  申请人：UNIV MIAMI

  公开号：WO2016022567A2

  公开（公告）日：2016-02-11

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof ("PUFAs") to modulate Iks channels to treat conditions associated with a disruption in Iks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pKa values, which can activate (i.e., open) IKs channels, and positively charged PUFAs that can inhibit (i.e., close) IKS channels.
• CN116211801
  申请人：——

  公开号：——

  公开（公告）日：——