(5Z)-5-[[3-(dimethylamino)phenyl]methylidene]-3-(2-hydroxyethyl)-2-methylimidazol-4-one | 1397619-12-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (5Z)-5-[[3-(dimethylamino)phenyl]methylidene]-3-(2-hydroxyethyl)-2-methylimidazol-4-one
• CAS: 1397619-12-3
• 化学式: C₁₅H₁₉N₃O₂
• 分子量: 273.335
• InChiKey: LMMIFILIKIXKQP-UVTDQMKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  56.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-溴-N,N-二甲基苯胺 在 正丁基锂 、 sodium acetate 、 乙酸酐 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 为溶剂， 反应 113.25h， 生成 (5Z)-5-[[3-(dimethylamino)phenyl]methylidene]-3-(2-hydroxyethyl)-2-methylimidazol-4-one
  参考文献：
  名称：

  Site-Selective Hydrogen-Bonding-Induced Fluorescence Quenching of Highly Solvatofluorochromic GFP-like Chromophores

  摘要：

  The unconstrained green fluorescence protein (GFP)-like chromophore m-DMABDI displays a high solvatofluorochromicity in aprotic solvents, but the fluorescence is quenched in protic solvents. According to the site-specific intramolecularly hydrogen-bonded analogs 1OH and 2OH, the hydrogen bonding to the carbonyl oxygen is more important than that to the imino nitrogen of the imidazolinone group in the fluorescence quenching.

  DOI：

  10.1021/ol302237k

文献信息

• Site-Selective Hydrogen-Bonding-Induced Fluorescence Quenching of Highly Solvatofluorochromic GFP-like Chromophores
  作者：Guan-Jhih Huang、Jinn-Hsuan Ho、Ch. Prabhakar、Yi-Hung Liu、Shie-Ming Peng、Jye-Shane Yang

  DOI：10.1021/ol302237k

  日期：2012.10.5

  The unconstrained green fluorescence protein (GFP)-like chromophore m-DMABDI displays a high solvatofluorochromicity in aprotic solvents, but the fluorescence is quenched in protic solvents. According to the site-specific intramolecularly hydrogen-bonded analogs 1OH and 2OH, the hydrogen bonding to the carbonyl oxygen is more important than that to the imino nitrogen of the imidazolinone group in the fluorescence quenching.