2,3-dihydroxy indanone | 146117-60-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dihydroxy indanone
• 英文别名: 2,3-dihydroxy-2,3-dihydroinden-1-one
• CAS: 146117-60-4
• 化学式: C₉H₈O₃
• 分子量: 164.161
• InChiKey: ZCKMTMNZYBROQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHOD FOR THE SYNTHESIS OF 4-BENZOFURAN-CARBOXYLIC ACID
  申请人：Burgos Alain

  公开号：US20090131688A1

  公开（公告）日：2009-05-21

  The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: wherein R independently represents hydrogen or a linear or branched C 1 - 15 alkyl group. With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.

  该发明涉及一种合成4-苯并呋喃羧酸或其烷基酯的新方法。该方法的特点在于，根据下面的方案A2，对式（II）化合物进行芳香化反应以合成式（I）的化合物：其中R独立表示氢或直链或支链的C1-15烷基基团。通过这项发明，可以以良好的产率和非常高的纯度工业化合成4-苯并呋喃羧酸或其烷基酯。
• Process for the preparation of arylalkylamines and substituted arylalkylamines
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0481705A1

  公开（公告）日：1992-04-22

  Arylalkylamines (as a sulfate salt) e.g. tyramine sulfate, are prepared by reacting substituted or unsubstituted arylalkylketones with a lower alkylnitrite in the presence of hydrogen chloride in a dipolar aprotic solvent, then combining the reaction mixture with water and extracting it with a lower alkyl ester or alcohol to recover an aryl-α-oximinoalkylketone extract. The extract, combined with a supported hydrogenation catalyst (e.g. palladium on carbon) in a nonaqueous reaction medium of a major proportion of a mildly protic carboxylic acid (e.g. acetic acid) and a minor proportion of a srong inorganic acid (e.g. sulfuric acid), which is effective in the presence of the catalyst for secondary alcohol dehydration and active as an absorbant for water produced in the dehydration reaction, is hydrogenated to produce the arylalkylamine sulfate sale.

  芳烷基胺（作为硫酸盐），例如硫酸酪胺，是通过在氯化氢存在下，在二极性非 普罗溶剂中，使取代或未取代的芳烷基酮与低级亚硝酸烷基酯反应，然后将反应混 合物与水混合，并用低级烷基酯或醇萃取，以回收芳基-α-氧亚氨基烷基酮萃取物。该萃取物与支撑氢化催化剂（如碳上钯）在非水反应介质中结合，该反应介质主要成分为轻度质子羧酸（如乙酸），次要成分为强无机酸（如硫酸），在催化剂存在下，强无机酸对二次醇脱水有效，对脱水反应中产生的水有吸附作用，氢化反应生成出售的芳基烷基胺硫酸盐。
• DIHYDROXYINDANONE TYROSINE KINASE INHIBITORS
  申请人：PFIZER INC.

  公开号：EP0586479A1

  公开（公告）日：1994-03-16
• US5041669A
  申请人：——

  公开号：US5041669A

  公开（公告）日：1991-08-20
• US5198585A
  申请人：——

  公开号：US5198585A

  公开（公告）日：1993-03-30