potassium;2-[[3-[(1S)-1-carboxyethyl]imino-1,5-dimethyl-2-phenylpyrazol-4-yl]iminomethyl]phenolate | 1361504-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: potassium;2-[[3-[(1S)-1-carboxyethyl]imino-1,5-dimethyl-2-phenylpyrazol-4-yl]iminomethyl]phenolate
• CAS: 1361504-79-1
• 化学式: C₂₁H₂₁N₄O₃*K
• 分子量: 416.521
• InChiKey: ZFUOKEVYWMQOQW-UQKRIMTDSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.67
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  91.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  L-丙氨酸 、 4-(2-hydroxybenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 以75%的产率得到potassium;2-[[3-[(1S)-1-carboxyethyl]imino-1,5-dimethyl-2-phenylpyrazol-4-yl]iminomethyl]phenolate
  参考文献：
  名称：

  Inspired research on the DNA binding ability of 4-aminoantiprine derived mixed ligand complexes

  摘要：

  A novel 4-aminoantipyrine derived Schiff base and its four mixed ligand complexes have been synthesized and characterized. The binding properties of metal complexes with DNA have been investigated by electronic absorption spectra and viscosity measurements showing that the complexes have the ability of interaction with DNA by intercalative mode. The effect of the metal complexes on DNA was carried out by pUC19 DNA agarose gel electrophoresis at 50 V for 2 h. The damage effect of the added ascorbic acid into the medium is dependent on the free radicals produced from oxidation of ascorbic acid by molecular oxygen and this damage is considered to be reduced by the metal complexes. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2011.12.029