Methyl 2-methylbutyl ether | 32793-79-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 2-methylbutyl ether
• 英文别名: (2R)-1-methoxy-2-methylbutane
• CAS: 32793-79-6
• 化学式: C₆H₁₄O
• 分子量: 102.17
• InChiKey: XGLHRCWEOMNVKS-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009062308A1

  公开（公告）日：2009-05-22

  Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.

  式(I)的化合物：其中c、X、Y、R2、R4和R5如本文所定义，可用作HIV复制的抑制剂。
• [EN] VIRAL POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE POLYMÉRASE VIRALE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009076747A1

  公开（公告）日：2009-06-25

  Compounds of formula I: wherein X, R2, R3, R3a, R3b,R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

  式I的化合物：其中X，R2，R3，R3a，R3b，R5和R6在此处定义，可用作乙型肝炎病毒NS5B聚合酶的抑制剂。
• CHEMICAL COMPOUNDS
  申请人：AstraZeneca AB

  公开号：US20170305909A1

  公开（公告）日：2017-10-26

  The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

  该规范涉及到Formula (I)的化合物及其药用盐。该规范还涉及用于它们制备的过程和中间体，含有它们的药物组合物以及它们在治疗细胞增殖性疾病中的应用。
• [EN] INDAZOLE DERIVATIVES THAT DOWN-REGULATE THE ESTROGEN RECEPTOR AND POSSESS ANTI-CANCER ACTIVITY<br/>[FR] DÉRIVÉS D'INDAZOLE QUI RÉGULENT NÉGATIVEMENT LE RÉCEPTEUR D'ŒSTROGÈNE ET POSSÈDENT UNE ACTIVITÉ ANTICANCÉREUSE
  申请人：ASTRAZENECA AB

  公开号：WO2017182495A1

  公开（公告）日：2017-10-26

  The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

  该规范涉及到公式（I）的化合物及其药用盐。该规范还涉及到用于它们制备的工艺和中间体，含有它们的药物组合物以及它们在治疗细胞增殖紊乱中的应用。
• Fluorinated 2-arylbenzo heterocyclic compound with high affinity to A beta 946; plaques and containing chiral side chain substituent, and preparation method and usage thereof
  申请人：BEIJING ZHIBO BIO-MEDICAL TECHNOLOGY CO., LTD

  公开号：US20160207910A1

  公开（公告）日：2016-07-21

  A fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing a chiral side chain substituent, has a general formula (I) as follows: wherein X is N; Y is S or O; Z is N or CH; R 1 is a 5 or 6-substituent and is F is 19 F or 18 F; R 2 is NHCH 3 or N(CH 3 ) 2 . The compound of the present invention has high affinity to Aβ plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD.

  一种含有手性侧链取代基的氟代2-芳基苯并杂环化合物，对Aβ斑块具有高亲和力，其一般化学式（I）如下：其中X为N；Y为S或O；Z为N或CH；R1为5或6-取代基，F为19F或18F；R2为NH 或N(CH3)2。本发明的化合物对Aβ斑块具有高亲和力，可用于制备适当的放射性核素标记探针，用于早期诊断阿尔茨海默病。