4,5,5,5-tetrafluoro-4-trifluoromethyl-pent-2-en-1-ol | 83706-95-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,5,5,5-tetrafluoro-4-trifluoromethyl-pent-2-en-1-ol
• 英文别名: 4,5,5,5-Tetrafluoro-4-(trifluoromethyl)pent-2-en-1-ol；(E)-4,5,5,5-tetrafluoro-4-(trifluoromethyl)pent-2-en-1-ol
• CAS: 83706-95-0
• 化学式: C₆H₅F₇O
• 分子量: 226.094
• InChiKey: LJGTZTYTTFGFAE-OWOJBTEDSA-N

物化性质

• 沸点：
  54-55°C 34mm
• 密度：
  1.440±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 安全说明：
  S26,S36/37/39

反应信息

• 作为产物：
  描述：

  (4,5,5,5-tetrafluoro-2-iodo-4-trifluoromethyl)pentyl acetate 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 5.0h， 生成 [2,3,3,3-四氟-2-(三氟甲基)丙基]环氧乙烷 、 4,5,5,5-tetrafluoro-4-trifluoromethyl-pent-2-en-1-ol 、 (4,5,5,5-tetrafluoro-4-trifluoromethyl-pent-2-enyl) acetate
  参考文献：
  名称：

  Fluorinated epoxides

  摘要：

  Fluorinated iodoacetate (CF3)(2)CFCH(2)CHICH(2)OAe (1) (prepared by radical addition of perfluoroisopropyl iodide to allyl acetate) and fluorinated iodohydrin (CF3)(2)CFCH2CHICH2OH (2) (prepared from 1) were converted to the corresponding perfluoroalkylated oxirane (CF3)(2)CFCH2CH(-O-)CH2 (3) in the yield of 62%. The chemoselectivity of the oxirane formation appeared to be strongly dependent on the starting compound 1 or 2 and solvent used. Byproducts (CF3)(2)CFCH=CHCH2OH (4) and (CF3)(2)CFCH=CHCH2OAc (5) can form a major part of the products in the formation of epoxide 3. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(03)00006-x

文献信息

• Production Processes and Systems, Compositions, Surfactants, Monomer Units, Metal Complexes, Phosphate Esters, Glycols, Aqueous Film Forming Foams, and Foam Stabilizers
  申请人：Jackson Andrew

  公开号：US20090137773A1

  公开（公告）日：2009-05-28

  Compositions and methods for making compositions such as RF(Rτ)nQ are provided. The RF group can include at least two —CF3 groups, the Rτ group can be a group having at least two carbons, n can be at least 1, and the Q group can include one or more atoms of the periodic table of elements. RF-intermediates (RF(RT)nQg); Surfactants (RF(RT)nQs); Foam stabilizers (RF(RT)IIQFS); Metal complexes (RF(RT)IIQMC); Phosphate ester (RF(RT)HQPE); Polymers (RF(RT)IIQMU); Monomers (RF(RT)IIQM); Urethanes (RF(Rτ)nQu); and/or Glycols (RF(RT)IIQH) and methods for making the same are provided.

  本发明提供了制备RF（Rτ）nQ等组合物的方法和组合物。其中，RF基团可以包括至少两个—CF3基团，Rτ基团可以是具有至少两个碳的基团，n可以至少为1，而Q基团可以包括元素周期表中的一个或多个原子。本发明还提供了RF中间体（RF（Rτ）nQg）；表面活性剂（RF（Rτ）nQs）；泡沫稳定剂（RF（Rτ）IIQFS）；金属配合物（RF（Rτ）IIQMC）；磷酸酯（RF（Rτ）HQPE）；聚合物（RF（Rτ）IIQMU）；单体（RF（Rτ）IIQM）；脲（RF（Rτ）nQu）；以及/或者乙二醇（RF（Rτ）IIQH）和制备它们的方法。
• Novel aerosol formulation containing a polar fluorinated molecule
  申请人：——

  公开号：US20030194378A1

  公开（公告）日：2003-10-16

  The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.

  本发明涉及一种用于吸入的稳定药用气溶胶制剂。该制剂含有一种活性物质、一种气溶胶推进剂、一种极性氟化分子和一种赋形剂。优选的推进剂是 HFA 134a 或 HFA 227 或它们的混合物。
• NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE
  申请人：AstraZeneca AB

  公开号：EP1303258A1

  公开（公告）日：2003-04-23
• PRODUCTION PROCESSES AND SYSTEMS, COMPOSITIONS, SURFACTANTS, MONOMER UNITS, METAL COMPLEXES, PHOSPHATE ESTERS, GLYCOLS, AQUEOUS FILM FORMING FOAMS, AND FOAM STABILIZERS
  申请人：GREAT LAKES CHEMICAL CORPORATION

  公开号：EP1907343A2

  公开（公告）日：2008-04-09
• Telomer compositions and production processes
  申请人：Ameduri Bruno

  公开号：US20080076892A1

  公开（公告）日：2008-03-27

  Telomer compositions are provided that can include at least one taxogen unit and a telogon unit, the taxogen unit being one or more of TFP, PFP, VDF, TFMA, PMVE, VF, TFE, CTFE, BrTFE, HFP, dichlorodifluoroethylene, chlorodifluoroethylene, bromodifluoroethylene, ethylenealkyl ether, ethylene, and propylene; the telogen unit being one or more of R F Q or R Cl Q, wherein the R F group can be an alkyl group having at least four fluorine atoms, the R Cl group can be —CCl 3 , and the Q group can be H, Br, or I. Chemical production processes are also provided that can include exposing a taxogen to a telogen to form a telomer.