2,6-Bis[4-[(2,4-dioxo-5-thiazolidinyl)methyl]phenoxy]naphthalene | 150053-33-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,6-Bis[4-[(2,4-dioxo-5-thiazolidinyl)methyl]phenoxy]naphthalene
• 英文别名: 5-[[4-[6-[4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]naphthalen-2-yl]oxyphenyl]methyl]-1,3-thiazolidine-2,4-dione
• CAS: 150053-33-1
• 化学式: C₃₀H₂₂N₂O₆S₂
• 分子量: 570.646
• InChiKey: PTVURJNAEVSUOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  161
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NOVEL BISHETEROCYCLIC DERIVATIVE OR SALT THEREOF
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0597102A1

  公开（公告）日：1994-05-18

  A bisheterocyclic compound represented by general formula (I), stereoisomers thereof, tautomers thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a pharmaceutical composition containing the same, and a process for the production thereof. In formula (I), R¹ and R² may be the same or different from each other and each represents (II) or (III), R3 represents hydrogen or a protective group, X, Y¹ and Y² may be the same or different from one another and each represents oxygen or sulfur, B¹ and B² represent each phenylene, B³ represents phenylene, naphthylene, cyclohexylene or furo[3,2-b]furanylene, L¹ and L² represent each -(O)n-A-, n represents 0 or 1, and A represents a single bond or lower alkylene, provided that when n is 1, A represents alkylene and the oxygen atom of each of L¹ and L² is bonded to B³. The above compounds are useful as a hypoglycemic drug based on the activity of enhancing insulin sensitivity.

  一种由通式(I)表示的双杂环化合物、其立体异构体、其同系物、其药学上可接受的盐或药学上可接受的溶液、含有其的药物组合物以及其生产工艺。在式(Ⅰ)中，R¹和R²可以相同或互不相同，各自代表(Ⅱ)或(Ⅲ)，R3代表氢或保护基团，X、Y¹和Y²可以相同或互不相同，各自代表氧或硫，B¹和B²各自代表亚苯基、L¹ 和 L² 分别代表-(O)n-A-，n 代表 0 或 1，A 代表单键或低级亚烷基，但当 n 为 1 时，A 代表亚烷基，且 L¹ 和 L² 的氧原子分别与 B³ 键合。基于提高胰岛素敏感性的活性，上述化合物可用作降血糖药物。
• NOVEL BISHETEROCYCLIC DERIVATIVE OR SALT THEREOF AND HYPOGLYCEMIC COMPOSITION
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0597102B1

  公开（公告）日：1999-01-07
• US5508296A
  申请人：——

  公开号：US5508296A

  公开（公告）日：1996-04-16