5,6-dichloro-N-(1-methylethyl)-1-β-D-ribopyranosyl-1H-benzimidazol-2-amine | 217950-63-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,6-dichloro-N-(1-methylethyl)-1-β-D-ribopyranosyl-1H-benzimidazol-2-amine
• 英文别名: (2R,3R,4R,5R)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]oxane-3,4,5-triol
• CAS: 217950-63-5
• 化学式: C₁₅H₁₉Cl₂N₃O₄
• 分子量: 376.24
• InChiKey: WXZYRKDMQCTYPO-AAVRWANBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  99.8
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• BENZIMIDAZOLE DERIVATIVES
  申请人：——

  公开号：US20020094963A1

  公开（公告）日：2002-07-18

  The present invention relates to certain bezimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.

  本发明涉及某些苯并咪唑衍生物及其在医学治疗中的应用，特别是用于治疗或预防由疱疹病毒引起的病毒感染。该发明还涉及苯并咪唑衍生物的制备以及含有它们的药物配方。
• MARIBAVIR ISOMERS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING
  申请人：Peabody John D.

  公开号：US20120283210A1

  公开（公告）日：2012-11-08

  The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.
• US6455507B1
  申请人：——

  公开号：US6455507B1

  公开（公告）日：2002-09-24
• US8940707B2
  申请人：——

  公开号：US8940707B2

  公开（公告）日：2015-01-27
• [EN] BENZIMIDAZOLE DERIVATIVES<br/>[FR] DERIVES DE BENZIMIDAZOLE
  申请人：——

  公开号：WO1998056761A2

  公开（公告）日：1998-12-17

  [EN] The present invention relates to certain bezimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
  [FR] La présente invention concerne certains dérivés de benzimidazole et leur utilisation en thérapie médicale, en particulier, pour la prophylaxie des infections par virus, comme celles provoquées par les virus de l'herpès. L'invention concerne également la préparation de dérivés de benzimidazole, et de formulations pharmaceutiques contenant ces dérivés.