(2-butoxybenzoyl)-4-[ 1-(3-((3-(2-hydroxyethoxy)phenyl)oxy)-4-cyanobenzyl)-2-methyl-5-imidazolylmethyl]piperazine | 356517-31-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-butoxybenzoyl)-4-[ 1-(3-((3-(2-hydroxyethoxy)phenyl)oxy)-4-cyanobenzyl)-2-methyl-5-imidazolylmethyl]piperazine
• 英文别名: 4-[[5-[[4-(2-Butoxybenzoyl)piperazin-1-yl]methyl]-2-methylimidazol-1-yl]methyl]-2-[3-(2-hydroxyethoxy)phenoxy]benzonitrile
• CAS: 356517-31-2
• 化学式: C₃₆H₄₁N₅O₅
• 分子量: 623.752
• InChiKey: BSOFRVQLJDKNPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Inhibitors of prenyl-protein transferase
  申请人：——

  公开号：US20020193283A1

  公开（公告）日：2002-12-19

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.

  本发明涵盖了含有哌嗪的化合物，可以抑制前尼基蛋白转移酶，包括法尼基-蛋白转移酶和戈南基戈南基-蛋白转移酶I型。这些治疗性化合物在癌症治疗中非常有用。
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA PRENYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2001060458A2

  公开（公告）日：2001-08-23

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.