glucosyl-D-fucoside | 208041-60-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: glucosyl-D-fucoside
• 英文别名: Glc(?1-1?)D-Fuc；(2R,3R,4S,5R)-2-methyl-6-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol
• CAS: 208041-60-5
• 化学式: C₁₂H₂₂O₁₀
• 分子量: 326.301
• InChiKey: BONDRAOAQXIYSR-MDESKBSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• Linkable sialyl lewis x analogs
  申请人：——

  公开号：US20040097403A1

  公开（公告）日：2004-05-20

  Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe X compositions. In particular, the disclosed SLe X compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLe X compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le x , and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.

  本文披露了一类可连接的四糖化合物，包括唾液酸Lewis X（SLeX）的氨基苯基糖苷及相关类似物。这些化合物具有可共轭的亲核基团，使它们在制备多聚SLeX组分时非常有用。具体而言，披露的SLeX化合物可用于通过将它们与报告基团（如对比剂、放射诊断剂或细胞毒性或化疗剂）连接起来制备选择素结合配体共轭物。本发明的SLeX化合物和共轭物表现出与天然唾液酸Lex相似的选择素结合能力，因此对于诊断和治疗选择素介导的疾病及相关病症非常有用。
• Linkable Lewis X Analogs
  申请人：Ranganathan Ramachandran

  公开号：US20080300220A1

  公开（公告）日：2008-12-04

  Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe X compositions. In particular, the disclosed SLe X compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLe X compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le X , and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.

  本发明涉及一类可连接的四糖化合物，其中包括唾液酸Lewis X（SLeX）的氨基苯基糖苷和相关类似物。这些化合物具有可共轭的亲核基团，使它们在制备多聚SLeX组分方面非常有用。特别是，所披露的SLeX化合物可用于通过将它们连接到报告者基团（如对比剂、放射诊断剂或细胞毒素或化学治疗剂）来制备选择素结合配体共轭物。本发明的SLeX化合物和共轭物表现出与天然唾液酸LeX类似的选择素结合性，因此，它们对于诊断和治疗选择素介导的疾病和相关病症非常有用。
• LINKABLE LEWIS X ANALOGS
  申请人：Ranganathan Ramachandran

  公开号：US20110229409A1

  公开（公告）日：2011-09-22

  Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe X compositions. In particular, the disclosed SLe X compounds can be used to prepare selectin binding ligand con-jugatcs by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLe X compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Le X , and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.

  本文披露了一类可连接四糖化合物，其中包括唾液酸Lewis X（SLeX）的氨基苯基糖苷和相关类似物。这些化合物具有可共轭的亲核基团，因此它们在制备多聚SLeX组分方面是有用的。特别地，所披露的SLeX化合物可用于通过将它们与报告物质（如对比剂、放射性诊断剂或细胞毒素或化疗剂）连接起来，制备选择素结合配体共轭物。本发明的SLeX化合物和共轭物表现出与天然唾液酸LeX相似的选择素结合性，因此可用于诊断和治疗选择素介导的疾病和相关病症。
• Trehalose phosphorylase, its preparation and uses
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP0841397A2

  公开（公告）日：1998-05-13

  A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and β-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with β-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.

  一种可从热花生菌属微生物中获得的热稳定性脱卤糖磷酸化酶，它能在无机磷酸存在下水解脱卤糖，生成 D-葡萄糖和 β-D-葡萄糖-1-磷酸。也可以通过 DNA 重组技术制备妥尔糖磷酸化酶。在有其他糖类存在的情况下，让酶与β-D-葡萄糖-1-磷酸作为糖类供体接触，就能以相对较低的成本在工业规模上生产出葡萄糖基转移的糖类，包括葡萄糖基-D-半乳糖苷。
• LINKABLE SIALYL LEWIS X ANALOGS
  申请人：Bracco International B.V.

  公开号：EP1337539A2

  公开（公告）日：2003-08-27