8-nitro-10-(5-nitro-1H-indol-3-yl)-5,10-dihydroindeno[1,2-b]indole | 1527500-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-nitro-10-(5-nitro-1H-indol-3-yl)-5,10-dihydroindeno[1,2-b]indole
• CAS: 1527500-62-4
• 化学式: C₂₃H₁₄N₄O₄
• 分子量: 410.389
• InChiKey: YXRODSPSJSNSCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,3'-((2-bromophenyl)methylene)bis(5-nitro-1H-indole) 在 cesium acetate 、 palladium diacetate 、 三苯基膦 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.0h， 以75%的产率得到8-nitro-10-(5-nitro-1H-indol-3-yl)-5,10-dihydroindeno[1,2-b]indole
  参考文献：
  名称：

  Intramolecular Pd-catalyzed C–H functionalization: construction of fused tetracyclic bis-indole alkaloid analogues

  摘要：

  An efficient Pd-catalyzed intramolecular indole-C2-arylation protocol for the synthesis of pharmaceutically active bis-indole alkaloid analogues from simple and readily available and 3,3'-Bis(1H-indo1-3-y1) methanes derivatives has been developed. The corresponding products could be obtained in moderate to excellent yields, which permits selective modification on either one of the two indole moieties independently. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.11.079

文献信息

• Intramolecular Pd-catalyzed C–H functionalization: construction of fused tetracyclic bis-indole alkaloid analogues
  作者：Xue-Qiang Chu、You Zi、Xin-Mou Lu、Shun-Yi Wang、Shun-Jun Ji

  DOI：10.1016/j.tet.2013.11.079

  日期：2014.1

  An efficient Pd-catalyzed intramolecular indole-C2-arylation protocol for the synthesis of pharmaceutically active bis-indole alkaloid analogues from simple and readily available and 3,3'-Bis(1H-indo1-3-y1) methanes derivatives has been developed. The corresponding products could be obtained in moderate to excellent yields, which permits selective modification on either one of the two indole moieties independently. (C) 2013 Elsevier Ltd. All rights reserved.