N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-2-[4-(hydroxymethyl)phenoxy]acetamide | 1566585-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-2-[4-(hydroxymethyl)phenoxy]acetamide
• CAS: 1566585-86-1
• 化学式: C₁₅H₂₄N₂O₅
• 分子量: 312.366
• InChiKey: CAZYILDBGRCWRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-2-[4-(hydroxymethyl)phenoxy]acetamide 、 甲基丙烯酰氯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以82%的产率得到N-[2-[2-[2-[[2-[4-(hydroxymethyl)phenoxy]acetyl]amino]ethoxy]ethoxy]ethyl]-2-methylprop-2-enamide
  参考文献：
  名称：

  Purification of Synthetic Peptides Using a Catching Full-Length Sequence by Polymerization Approach

  摘要：

  During automated solid-phase peptide synthesis, failure sequences were capped with acetic anhydride. After synthesis, a polymerizable methacrylamide tag was attached to the full-length sequences. Peptide purification was then achieved by polymerizing the full-length sequences, washing away impurities, and cleaving the peptide product from the polymer.

  DOI：

  10.1021/ol403426u
• 作为产物：
  描述：

  对羟基苯甲醇 在 potassium carbonate 、 potassium iodide 作用下， 以 水 、 丙酮 为溶剂， 反应 17.0h， 生成 N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-2-[4-(hydroxymethyl)phenoxy]acetamide
  参考文献：
  名称：

  Purification of Synthetic Peptides Using a Catching Full-Length Sequence by Polymerization Approach

  摘要：

  During automated solid-phase peptide synthesis, failure sequences were capped with acetic anhydride. After synthesis, a polymerizable methacrylamide tag was attached to the full-length sequences. Peptide purification was then achieved by polymerizing the full-length sequences, washing away impurities, and cleaving the peptide product from the polymer.

  DOI：

  10.1021/ol403426u