tert-butyl N-hydroxy-N-[(2R)-1-hydroxypropan-2-yl]carbamate | 1569092-83-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl N-hydroxy-N-[(2R)-1-hydroxypropan-2-yl]carbamate
• CAS: 1569092-83-6
• 化学式: C₈H₁₇NO₄
• 分子量: 191.227
• InChiKey: OBADJJITOFXDES-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-羟基氨基甲酸叔丁酯 在 manganese(IV) oxide 、 sodium tetrahydroborate 、 (2R)-2-tritylpyrrolidine 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 20.5h， 生成 tert-butyl N-hydroxy-N-[(2R)-1-hydroxypropan-2-yl]carbamate
  参考文献：
  名称：

  Practical Approach for Asymmetric Hydroxyamination of Aldehydes with in Situ Generated Nitrosocarbonyl Compounds: Application to One-Pot Synthesis of Chiral Allylamines

  摘要：

  The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.

  DOI：

  10.1021/ol5000742

文献信息

• Practical Approach for Asymmetric Hydroxyamination of Aldehydes with <i>in Situ</i> Generated Nitrosocarbonyl Compounds: Application to One-Pot Synthesis of Chiral Allylamines
  作者：Taichi Kano、Fumitaka Shirozu、Keiji Maruoka

  DOI：10.1021/ol5000742

  日期：2014.3.7

  The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.