(4R,4aS,5R,6S,7R,8S,8aS)-5,6,7-Tris-benzyloxy-4-methoxymethoxy-octahydro-chromen-8-ol | 220207-68-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R,4aS,5R,6S,7R,8S,8aS)-5,6,7-Tris-benzyloxy-4-methoxymethoxy-octahydro-chromen-8-ol
• CAS: 220207-68-1
• 化学式: C₃₂H₃₈O₇
• 分子量: 534.65
• InChiKey: JKSMMLJTWQXFHH-WPOGHVOLSA-N

反应信息

• 作为反应物：
  描述：

  (4R,4aS,5R,6S,7R,8S,8aS)-5,6,7-Tris-benzyloxy-4-methoxymethoxy-octahydro-chromen-8-ol 在 乙酸酐 、 L-Selectride 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成 (4R,4aS,5R,6S,7R,8R,8aS)-5,6,7-Tris-benzyloxy-4-methoxymethoxy-octahydro-chromen-8-ol
  参考文献：
  名称：

  Synthesis of Bicyclic Derivatives of 5a-Carba-sugars: 6-Hydroxyl Group Conformationally Restricted 5a-Carba-D-mannopyranose Derivatives

  摘要：

  Some bicyclic derivatives of 5a-carba-alpha- and beta-D-mannopyranoses, whose 6-hydroxyl groups are conformationally restricted, have been synthesized in order to provide key components of the trisaccharide mimics designed as inhibitors or substrate analogues useful for elucidation of mechanism and action of GlcNAcT-V.

  DOI：

  10.3987/com-98-s(h)42
• 作为产物：
  描述：

  Toluene-4-sulfonic acid 3-methoxymethoxy-3-((1R,2R,3S,4R,5S,6S)-2,3,4-tris-benzyloxy-5,6-dihydroxy-cyclohexyl)-propyl ester 、 Toluene-4-sulfonic acid 3-methoxymethoxy-3-[(1R,2R,3S,4S,5S,6S)-2,3,4-tris-benzyloxy-5,6-bis-(4-methoxy-benzyloxy)-cyclohexyl]-propyl ester 在 ammonium cerium(IV) nitrate 、 sodium methylate 作用下， 以 水 、 乙腈 、 甲醇 为溶剂， 以39%的产率得到(4R,4aS,5R,6S,7R,8S,8aS)-5,6,7-Tris-benzyloxy-4-methoxymethoxy-octahydro-chromen-8-ol
  参考文献：
  名称：

  Synthesis of Bicyclic Derivatives of 5a-Carba-sugars: 6-Hydroxyl Group Conformationally Restricted 5a-Carba-D-mannopyranose Derivatives

  摘要：

  Some bicyclic derivatives of 5a-carba-alpha- and beta-D-mannopyranoses, whose 6-hydroxyl groups are conformationally restricted, have been synthesized in order to provide key components of the trisaccharide mimics designed as inhibitors or substrate analogues useful for elucidation of mechanism and action of GlcNAcT-V.

  DOI：

  10.3987/com-98-s(h)42