5-(2-Methoxy-ethyl)-5-[4-(2-pyridin-2-yl-2H-indazol-5-yloxy)-phenoxy]-pyrimidine-2,4,6-trione | 620989-55-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(2-Methoxy-ethyl)-5-[4-(2-pyridin-2-yl-2H-indazol-5-yloxy)-phenoxy]-pyrimidine-2,4,6-trione
• 英文别名: 5-(2-Methoxyethyl)-5-[4-(2-pyridin-2-ylindazol-5-yl)oxyphenoxy]-1,3-diazinane-2,4,6-trione
• CAS: 620989-55-1
• 化学式: C₂₅H₂₁N₅O₆
• 分子量: 487.472
• InChiKey: HYEVBFXAMLDAAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
  申请人：Pfizer Inc.

  公开号：US20030232849A1

  公开（公告）日：2003-12-18

  The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula 1 wherein X, A, Y, B, G, and R 1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

  本发明涉及公式1中的N-取代-杂环氧基-芳氧基-2,4,6-三酮金属蛋白酶抑制剂，其中X、A、Y、B、G和R1如规范中所定义，并涉及用于治疗炎症、癌症和其他疾病的药物组合物和方法。
• PYRIMIDINE-2,4,6-TRIONE METALLO-PROTEINASE INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1507535A1

  公开（公告）日：2005-02-23
• US6919332B2
  申请人：——

  公开号：US6919332B2

  公开（公告）日：2005-07-19
• [EN] PYRIMIDINE-2, 4, 6-TRIONE METALLO-PROTEINASE INHIBITORS<br/>[FR] INHIBITEURS DE METALLOPROTEINASE A BASE DE PYRIMIDINE-2, 4, 6-TRIONE
  申请人：PFIZER PROD INC

  公开号：WO2003090751A1

  公开（公告）日：2003-11-06

  The present invention relates to N-substituted-heteroaryloxy-aryloxy-2, 4, 6-trione metalloproteinase inhibitors of the formula (I) wherein X, A, Y, B, G and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders. The compounds are matrix metalloproteinase (MMP) inhibitors.