Bisindole Alkaloids with Neural Anti-inflammatory Activity from <i>Gelsemium elegans</i>
作者:Jing Qu、Lei Fang、Xiao-Dong Ren、Yunbao Liu、Shi-Shan Yu、Li Li、Xiu-Qi Bao、Dan Zhang、Yong Li、Shuang-Gang Ma
DOI:10.1021/np4005536
日期:2013.12.27
Three new trace bisindole alkaloids geleganimines A and B (1, 2) and geleganamide (3) were isolated from the aerial parts of Gelsemium elegans. Their structures were elucidated by spectroscopy, particularly from their carbon-proton coupling constants, and electronic circular dichroism. Compounds 1-3 are the first bisindole alkaloids discovered from the genus Gelsemium. Geleganimine B exhibited anti-inflammatory activity indirectly by suppressing lipopolysaccharide-induced pro. inflammatory factors in BV2 microglial cells with an IC50 value of 10.2 mu M. These findings confirm the importance of bioactive trace components in medicinal plant research.