(2R,3R,4S,5S,6R)-2-[[1-[[4-[4-[3,3,4,4,5,5-hexafluoro-2-[2-methyl-5-[4-[[4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]methyl]phenyl]thiophen-3-yl]cyclopenten-1-yl]-5-methylthiophen-2-yl]phenyl]methyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 1536084-90-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5S,6R)-2-[[1-[[4-[4-[3,3,4,4,5,5-hexafluoro-2-[2-methyl-5-[4-[[4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]methyl]phenyl]thiophen-3-yl]cyclopenten-1-yl]-5-methylthiophen-2-yl]phenyl]methyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1536084-90-8
• 化学式: C₄₇H₄₈F₆N₆O₁₂S₂
• 分子量: 1067.05
• InChiKey: HIUMVARSAGYEQG-WRVQMMDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  73
• 可旋转键数：
  16
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  317
• 氢给体数：
  8
• 氢受体数：
  24

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,5S,6R)-2-[[1-[[4-[4-[3,3,4,4,5,5-hexafluoro-2-[2-methyl-5-[4-[[4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]methyl]phenyl]thiophen-3-yl]cyclopenten-1-yl]-5-methylthiophen-2-yl]phenyl]methyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol 以 水 为溶剂， 生成 (2R,3R,4S,5S,6R)-2-[[1-[[4-[8,8,9,9,10,10-hexafluoro-1,2-dimethyl-14-[4-[[4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]methyl]phenyl]-3,15-dithiatetracyclo[10.3.0.02,6.07,11]pentadeca-4,6,11,13-tetraen-4-yl]phenyl]methyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  The effects of phenyl-bridged glucosyltriazolyl groups on the properties of water-soluble diarylethene derivatives

  摘要：

  Three water-soluble diarylethenes with glycosyltriazolyl groups and variable phenyl units have been synthesized, and their properties, such as water solubility, photochromism, and fluorescence have been discussed. Upon alternating irradiation with UV and visible light, each of the diarylethenes exhibited favorable photochromism and functioned as fluorescent switches in water. Experimental results showed that their water solubility as well as absorption features, cyclization quantum yields, photoconversion ratios, thermal stability, and fatigue resistance exhibited a strong correlation with the number of phenyl-bridged glucosyltriazolyl groups in diarylethene systems. The absorption maximum, thermal stability, and fatigue resistance were significantly improved, but the water solubility and fluorescent modulation efficiency were suppressed with the increase of the number of phenyl-bridged glucosyltriazolyl groups for these diarylethene derivatives. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.12.037
• 作为产物：
  描述：

  [(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-[[1-[[4-[4-[3,3,4,4,5,5-hexafluoro-2-[2-methyl-5-[4-[[4-[[(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]methyl]phenyl]thiophen-3-yl]cyclopenten-1-yl]-5-methylthiophen-2-yl]phenyl]methyl]triazol-4-yl]methoxy]oxan-2-yl]methyl acetate 在 水 、 sodium hydroxide 作用下， 反应 24.0h， 以93%的产率得到(2R,3R,4S,5S,6R)-2-[[1-[[4-[4-[3,3,4,4,5,5-hexafluoro-2-[2-methyl-5-[4-[[4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]methyl]phenyl]thiophen-3-yl]cyclopenten-1-yl]-5-methylthiophen-2-yl]phenyl]methyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  The effects of phenyl-bridged glucosyltriazolyl groups on the properties of water-soluble diarylethene derivatives

  摘要：

  Three water-soluble diarylethenes with glycosyltriazolyl groups and variable phenyl units have been synthesized, and their properties, such as water solubility, photochromism, and fluorescence have been discussed. Upon alternating irradiation with UV and visible light, each of the diarylethenes exhibited favorable photochromism and functioned as fluorescent switches in water. Experimental results showed that their water solubility as well as absorption features, cyclization quantum yields, photoconversion ratios, thermal stability, and fatigue resistance exhibited a strong correlation with the number of phenyl-bridged glucosyltriazolyl groups in diarylethene systems. The absorption maximum, thermal stability, and fatigue resistance were significantly improved, but the water solubility and fluorescent modulation efficiency were suppressed with the increase of the number of phenyl-bridged glucosyltriazolyl groups for these diarylethene derivatives. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.12.037