1-Phenyl-2-(1-pyrrolidinyl)-1-hexanone | 13415-86-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Phenyl-2-(1-pyrrolidinyl)-1-hexanone
• 英文别名: 1-phenyl-2-pyrrolidin-1-ylhexan-1-one
• CAS: 13415-86-6
• 化学式: C₁₆H₂₃NO
• 分子量: 245.36
• InChiKey: KYIJLDDXQWBNGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Method for isolating cross-reactive aptamer and use thereof
  申请人：Yang Weijuan

  公开号：US10655132B1

  公开（公告）日：2020-05-19

  The subject invention provides a novel SELEX strategy for isolating cross-reactive aptamers that recognize a core structure of a small-molecule family and bind to each structurally-similar molecule in said family. The subject invention also provides methods, assays, and products for detecting small-molecule targets of the family in a sample in both clinical and field settings. Such method is based on an aptamer sensor that reports the presence of small-molecule targets via a sensitive colorimetric signal for naked-eye detection. The subject invention further provides exonuclease-based methods for generating structure-switching aptamers from fully folded aptamers and developing electrochemical aptamer-based (E-AB) sensors for rapid and sensitive detection of synthetic cathinones.

  本发明提供了一种新颖的 SELEX 策略，可用于分离交叉反应的适配体，这种适配体可识别小分子家族的核心结构，并与所述家族中结构相似的每个分子结合。本发明还提供了在临床和现场环境中检测样本中该家族小分子靶标的方法、检测方法和产品。这种方法基于一种适配体传感器，该传感器通过灵敏的比色信号报告小分子靶标的存在，供肉眼检测。本发明进一步提供了基于外切核酸酶的方法，用于从完全折叠的适配体生成结构开关适配体，并开发了基于电化学适配体的传感器（E-AB），用于快速灵敏地检测合成卡西酮。
• Materials and methods for rapid and specific detection of synthetic cathinones
  申请人：Xiao Yi

  公开号：US10683507B2

  公开（公告）日：2020-06-16

  The subject invention provides methods, assays, and products for detecting small molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target, preferably, a synthetic cathinone in a sample comprises contacting the sample with an aptamer-based sensor selective for the small-molecule target, and detecting the small-molecule target in the sample. Specifically, the method utilizes an aptamer-based sensor comprising a dye binding to a three-way junction binding domain of an aptamer. Binding of small-molecule target to the aptamer displaces the dye, generating a spectroscopic signal that can be used for detection of the small-molecule target and quantitative measurement of the target concentration.

  本发明提供了检测样品中小分子的方法、检测方法和产品，特别是在临床和现场环境中。检测样品中的小分子目标物（最好是合成卡西酮）的方法包括将样品与对小分子目标物有选择性的基于适配体的传感器接触，并检测样品中的小分子目标物。具体来说，该方法利用了一种基于适配体的传感器，该传感器包括与适配体的三向接合结合域结合的染料。小分子目标物与适配体结合会置换染料，产生光谱信号，该信号可用于检测小分子目标物和定量测量目标物浓度。
• Material and method for colorimetric detection of small-molecule targets
  申请人：Xiao Yi

  公开号：US10725058B2

  公开（公告）日：2020-07-28

  The subject invention provides methods, assays, and products for visual detection of small-molecule targets in a sample in both clinical and field settings within minutes. The subject invention is based on an aptamer sensor that reports the presence of small-molecule target via a sensitive colorimetric signal for naked-eye detection. The aptamer sensor is a CBSAzyme-based sensor having both target-mediated cooperative behavior of the CBSA and peroxidase-mimicking catalytic activity of DNAzyme. The subject invention also provides methods of using the CBSAzyme-based sensor.

  本发明提供了在临床和现场环境中几分钟内目视检测样品中小分子靶标的方法、检测方法和产品。本发明基于一种适配体传感器，该传感器通过灵敏的比色信号报告小分子靶标的存在，用于肉眼检测。该适配体传感器是一种基于 CBSA 酶的传感器，同时具有 CBSA 的目标介导合作行为和 DNA 酶的过氧化物酶模拟催化活性。本发明还提供了使用基于 CBSA 酶的传感器的方法。
• Methods for generating structure-switching aptamers and uses thereof
  申请人：Xiao Yi

  公开号：US11162960B2

  公开（公告）日：2021-11-02

  The subject invention provides methods, assays, and products for detecting small-molecule targets in a complex sample in both clinical and field settings. The subject invention provides aptamer-based sensors and methods of use thereof. The subject invention provides exonuclease-based methods for generating structure-switching aptamers from fully folded or pre-folded aptamers and developing aptamer-based sensors for small-molecule detection. The method for detecting one or more small-molecule targets in a sample comprises contacting the sample with one or more aptamer-based sensor selective for each of the small-molecule targets, and detecting the small-molecule target in the sample.

  本发明提供了在临床和现场环境中检测复杂样本中的小分子靶标的方法、检测方法和产品。本发明提供了基于适配体的传感器及其使用方法。本发明提供了基于外切核酸酶的方法，用于从完全折叠或预折叠的适配体生成结构转换适配体，并开发基于适配体的小分子检测传感器。检测样品中一种或多种小分子靶标的方法包括将样品与一种或多种对每种小分子靶标具有选择性的基于适配体的传感器接触，并检测样品中的小分子靶标。
• MATERIALS AND METHODS FOR RAPID AND SPECIFIC DETECTION OF SYNTHETIC CATHINONES
  申请人：XIAO Yi

  公开号：US20190256852A1

  公开（公告）日：2019-08-22

  The subject invention provides methods, assays, and products for detecting small molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target, preferably, a synthetic cathinone in a sample comprises contacting the sample with an aptamer-based sensor selective for the small-molecule target, and detecting the small-molecule target in the sample. Specifically, the method utilizes an aptamer-based sensor comprising a dye binding to a three-way junction binding domain of an aptamer. Binding of small-molecule target to the aptamer displaces the dye, generating a spectroscopic signal that can be used for detection of the small-molecule target and quantitative measurement of the target concentration.