4-Methoxypyridine-2-carbothioamide | 1256809-29-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methoxypyridine-2-carbothioamide
• CAS: 1256809-29-6
• 化学式: C₇H₈N₂OS
• 分子量: 168.22
• InChiKey: OMWKEIFJHWFZOD-UHFFFAOYSA-N

物化性质

• 沸点：
  329.6±52.0 °C(Predicted)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
  申请人：BUCKMAN Brad

  公开号：US20120101032A1

  公开（公告）日：2012-04-26

  The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

  本实施例提供了一般式I、Ia、II、IIa、III、IIIa、IV、IVa、V、Va、VI和VIa的化合物，以及包括药物组成物在内的组合物，其中包括一种主体化合物。本实施例还提供了治疗方法，包括治疗丙型肝炎病毒感染和治疗肝纤维化的方法，该方法通常涉及向需要治疗的个体施用一种主体化合物或组合物的有效量。
• [EN] NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION<br/>[FR] NOUVEAUX INHIBITEURS MACROCYCLIQUES DE LA RÉPLICATION DU VIRUS DE L'HÉPATITE C
  申请人：INTERMUNE INC

  公开号：WO2012054874A1

  公开（公告）日：2012-04-26

  The embodiments provide compounds of the general Formulae I, la, II, Ila, IIΙ, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.