3-Butoxy-2,2-dimethylcyclobutan-1-amine | 1376346-21-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Butoxy-2,2-dimethylcyclobutan-1-amine
• CAS: 1376346-21-2
• 化学式: C₁₀H₂₁NO
• mdl: MFCD21758059
• 分子量: 171.28
• InChiKey: YFXMXNXPRBEEAF-UHFFFAOYSA-N

物化性质

• 沸点：
  214.1±33.0 °C(Predicted)
• 密度：
  0.91±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
  申请人：Arvinas, Inc.

  公开号：US20170327469A1

  公开（公告）日：2017-11-16

  The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds Androgen Receptor such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of Androgen Receptor.