3-Methylene-hept-1-en-4-one | 50360-62-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Methylene-hept-1-en-4-one
• 英文别名: 3-Methylidenehept-1-en-4-one
• CAS: 50360-62-8
• 化学式: C₈H₁₂O
• 分子量: 124.183
• InChiKey: MZLUPNQXSKHWFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP2143724A1

  公开（公告）日：2010-01-13

  [Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

  [目的]本发明提供了可作为预防或治疗性激素依赖性疾病或类似疾病的药物的化合物。 [解决方案] 本发明提供了由以下通式（I）表示的具有 GnRH 拮抗活性的含氮融合环衍生物、原药、盐、含有这些衍生物的药物组合物及其药用用途等。式（I）中，环 A 和 B 独立地为芳基或杂芳基；RA 和 RB 独立地为卤素、氰基、烷基、烷基磺酰基、-OW1、-SW1、-COW2、-NW3W4、-SO2NW3W4、芳基等；RC 为 H 或烷基；E 为氧原子等。U 是单键或亚烷基；X 是 Y、-CO-Y、-SO2-Y -S-（亚烷基）-Y、-O-（亚烷基）-Y、-SO2-（亚烷基）-Y 等；Y 是 Z 或氨基等；Z 是环烷基、杂环烷基、芳基、杂芳基等。
• 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3009433A1

  公开（公告）日：2016-04-20

  Compounds of general formula (I) and pharmaceutically acceptable salts thereof having an excellent hypoglycemic effect and β cell- or pancreas-protecting effects are provided. Their pharmaceutical compositions have an excellent therapeutic and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause hyperglycemia due to abnormal glucose metabolism. Ring A represents *represents the bonding site with the benzene ring.

  本研究提供了通式（I）化合物及其药学上可接受的盐类，它们具有极佳的降血糖效果和保护β细胞或胰腺的作用。它们的药物组合物对 1 型糖尿病、2 型糖尿病等因糖代谢异常而导致的高血糖具有极佳的治疗和/或预防效果。 环 A 代表 *代表与苯环的结合部位。
• COMPOSITION FOR EXTRUDING FIBERS
  申请人：GAO FENG

  公开号：US20110126897A1

  公开（公告）日：2011-06-02

  The present invention relates a composition which is useful in printing by extruding a metalized fiber on a substrate. Zinc oxide is incorporated in combination with glass frit into a composition to etch the substrate and a binder polymer is used to allow extrusion of narrow fibers which also may have adequate height to provide sufficient electrical conduction. The present invention is also a process to extrude a pattern of the composition. The present invention is further directed to a solar cell formed from such composition and the process.