4-furanyl-1H-pyrrole-3-carboxylic acid ethyl ester | 1188164-52-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-furanyl-1H-pyrrole-3-carboxylic acid ethyl ester
• 英文别名: ethyl 4-(furan-2-yl)-1H-pyrrole-3-carboxylate
• CAS: 1188164-52-4
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.213
• InChiKey: LLSMAELVOBGSIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-furanyl-1H-pyrrole-3-carboxylic acid ethyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以84%的产率得到4-(furan-2-yl)-1H-pyrrole-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles

  摘要：

  A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds-ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial activity. Among the tested compounds pyrrolyl pyrimidine derivatives and chloro-substituted pyrroles displayed excellent activity when compared to the other compounds. The chloro-substituted pyrrolyl sulfonamides are the potent antimicrobial agents particularly against P. aeruginosa and P. chrysogenum.

  DOI：

  10.1007/s00044-014-0908-1
• 作为产物：
  描述：

  对甲基苯磺酰甲基异腈 、 环氧富锌底漆 以 乙醚 、 二甲基亚砜 为溶剂， 生成 4-furanyl-1H-pyrrole-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles

  摘要：

  A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds-ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial activity. Among the tested compounds pyrrolyl pyrimidine derivatives and chloro-substituted pyrroles displayed excellent activity when compared to the other compounds. The chloro-substituted pyrrolyl sulfonamides are the potent antimicrobial agents particularly against P. aeruginosa and P. chrysogenum.

  DOI：

  10.1007/s00044-014-0908-1