N-(2-methylacryloyl)salicylhydrazide | 1123162-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methylacryloyl)salicylhydrazide
• 英文别名: 2-[N-(2-methylprop-2-enoylamino)-C-oxoniocarbonimidoyl]phenolate
• CAS: 1123162-03-7
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: RBINUXCZGSUSDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  吡啶 、 N-(2-methylacryloyl)salicylhydrazide 、 copper(II) acetate monohydrate 以 N,N-二甲基甲酰胺 为溶剂， 生成 [Cu3(N-(2-methylacryloyl)salicylhydrazide(-3H))2(pyridine)2]
  参考文献：
  名称：

  Synthesis, characterization and bioactivity of two novel trinuclear Cu(II)/Ni(II) complexes with pentadentate ligand N-2-methyl-acryloyl-salicylhydrazide

  摘要：

  Two new trinuclear complexes, Cu3L2(py)(2) (1) and Ni3L2(py)(4) (2), have been synthesized and characterized, where L-3 is N-2-methyl-acryloyl-salicylhydrazidate. Central metal ion and two terminal metal ions in the two complexes are combined by two bridging deprotonated L-3 ligands, forming a bent trinuclear structure unit with an M-N-N-M-N-N-M core. The bent angles in complexes 1 and 2 are 167.6(1)degrees and 75.4(1)degrees, respectively. Three nickel ions in compound 2 exhibit alternating square-planar and octahedral geometries, while three copper ions in compound 1 follow square-planar mode. The studies in solution integrity and stability of compounds 1 and 2 show they are soluble and stable in DMF. UV-Vis titrations demonstrate compound 1 is stable in DMF even in the presence of excess metal ions. Antibacterial screening data indicate the two compounds all have stronger antimicrobial activities against the tested microorganisms than ligand. The trinuclear copper compound 1 is more active than monocopper compounds in the previous study, and the trinuclear nickel compound 2 is less active than tetranuclear nickel compound in the previous study. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2008.05.007

文献信息

• Synthesis, characterization and bioactivity of two novel trinuclear Cu(II)/Ni(II) complexes with pentadentate ligand N-2-methyl-acryloyl-salicylhydrazide
  作者：Wei Luo、Xiang-Gao Meng、Gong-Zhen Cheng、Zhen-Ping Ji

  DOI：10.1016/j.ica.2008.05.007

  日期：2009.1

  Two new trinuclear complexes, Cu3L2(py)(2) (1) and Ni3L2(py)(4) (2), have been synthesized and characterized, where L-3 is N-2-methyl-acryloyl-salicylhydrazidate. Central metal ion and two terminal metal ions in the two complexes are combined by two bridging deprotonated L-3 ligands, forming a bent trinuclear structure unit with an M-N-N-M-N-N-M core. The bent angles in complexes 1 and 2 are 167.6(1)degrees and 75.4(1)degrees, respectively. Three nickel ions in compound 2 exhibit alternating square-planar and octahedral geometries, while three copper ions in compound 1 follow square-planar mode. The studies in solution integrity and stability of compounds 1 and 2 show they are soluble and stable in DMF. UV-Vis titrations demonstrate compound 1 is stable in DMF even in the presence of excess metal ions. Antibacterial screening data indicate the two compounds all have stronger antimicrobial activities against the tested microorganisms than ligand. The trinuclear copper compound 1 is more active than monocopper compounds in the previous study, and the trinuclear nickel compound 2 is less active than tetranuclear nickel compound in the previous study. (C) 2008 Elsevier B.V. All rights reserved.