Diethyl 2-[anilino-(4-bromophenyl)methyl]propanedioate | 1092937-96-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Diethyl 2-[anilino-(4-bromophenyl)methyl]propanedioate
• 英文别名: diethyl 2-[anilino-(4-bromophenyl)methyl]propanedioate
• CAS: 1092937-96-6
• 化学式: C₂₀H₂₂BrNO₄
• 分子量: 420.303
• InChiKey: FLUAQTCONHMCLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对溴苯甲醛 、 苯胺 、 丙二酸二乙酯 在 lithium perchlorate 作用下， 反应 5.0h， 生成 Diethyl 2-[anilino-(4-bromophenyl)methyl]propanedioate
  参考文献：
  名称：

  LiClO₄-Accelerated Three-Component Mannich-Type Reaction of Diethyl Malonate with Imines: An Efficient Synthesis of β-Amino Esters Under Solvent-Free Conditions

  摘要：

  LiClO4 is used as catalyst for direct Mannich-type reaction of aryl aldehydes, aryl amines, and diethyl malonic ester under solvent-free conditions. This three-component reaction afforded the corresponding-amino esters in good yields with simple and environmentally benign procedure.

  DOI：

  10.1080/00397910802271297

文献信息

• LiClO₄-Accelerated Three-Component Mannich-Type Reaction of Diethyl Malonate with Imines: An Efficient Synthesis of <font>β</font>-Amino Esters Under Solvent-Free Conditions
  作者：Fezzeh Aryanasab、Mohammad R. Saidi

  DOI：10.1080/00397910802271297

  日期：2008.10.28

  LiClO4 is used as catalyst for direct Mannich-type reaction of aryl aldehydes, aryl amines, and diethyl malonic ester under solvent-free conditions. This three-component reaction afforded the corresponding-amino esters in good yields with simple and environmentally benign procedure.