2-tert-butoxy-3-chloropyridine | 1289149-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-tert-butoxy-3-chloropyridine
• 英文别名: 3-Chloro-2-[(2-methylpropan-2-yl)oxy]pyridine
• CAS: 1289149-07-0
• 化学式: C₉H₁₂ClNO
• 分子量: 185.653
• InChiKey: FUTBKFVZXQPTHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS
  申请人：Pfizer Limited

  公开号：EP2593431B1

  公开（公告）日：2014-11-19
• N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS
  申请人：Pfizer Limited

  公开号：EP2593432B1

  公开（公告）日：2014-10-22
• Combination of Kinase Inhibitors and Uses Thereof
  申请人：INTELLIKINE, LLC

  公开号：US20160089371A1

  公开（公告）日：2016-03-31

  The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject.
• COMBINATION OF MTOR INHIBITORS AND PI3-KINASE INHIBITORS, AND USES THEREOF
  申请人：Intellikine LLC

  公开号：US20160235758A1

  公开（公告）日：2016-08-18

  The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.