α-Oxocyclohexanepentanenitrile | 133537-19-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-Oxocyclohexanepentanenitrile
• 英文别名: 4-Cyclohexylbutanoyl cyanide
• CAS: 133537-19-6
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: JEQMWNLHWCAEES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasopastic disease
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0403090A1

  公开（公告）日：1990-12-19

  7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula wherein m is 1, 2 or 3; n is 1, 2 or 3 and p is 1, 2 or 3; R is C02H, CO2lower alkyl, CO2alkali metal, CONHS02 R2 (wherein R2 is lower alkyl or aryl) or 5-tetrazolyl; A is CHOH, C=O, (wherein R3 is H or lower alkyl), or a single bond; R, is lower alkyl, aryl, cycloalkyl or H, R1 can be H only when A is a single bond.

  7-氧杂双环庚烷咪唑类前列腺素类似物可用于治疗血栓性疾病和血管痉挛性疾病，其结构式为 其中m为1、2或3；n为1、2或3，p为1、2或3；R为C02H、CO2低级烷基、 碱金属、CONHS02 R2（其中R2为低级烷基或芳基）或5-四唑基；A为CHOH、C=O、 (其中 R3 为 H 或低级烷基）或单键；R 为低级烷基、芳基、环烷基或 H，R1 只有在 A 为单键时才可以是 H。
• 7-Oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic diseases
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0447188A2

  公开（公告）日：1991-09-18

  7-Oxabicycoheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula wherein m is 0, 1, 2, 3 or 4; n is 1, 2 or 3; and p is 1, 2 or 3; Z is -CH=CH-, -CH2CH2- or wherein Y is 0 or a single bond ; R is C02H, CO2lower alkyl, C02alkali metal, CONHS02R2 (wherein R2 is lower alkyl or aryl) or -CH2-5-tetrazolyl; A is CHOH, C=O, (wherein R3 is H or lower alkyl), or a single bond ; R1 is lower alkyl, aryl, cycloalkyl or H, R1 can be H only when A is a single bond.

  提供了可用于治疗血栓性和血管痉挛性疾病的 7-氧杂双环庚烷咪唑前列腺素类似物，其结构式为 其中m是0、1、2、3或4；n是1、2或3；p是1、2或3；Z是-CH=CH-、- -或- -。 其中 Y 是 0 或单键；R 是 C02H、CO2lower 烷基、C02 碱金属、CONHS02R2（其中 R2 是低级烷基或芳基）或 -CH2-5-四唑基；A 是 CHOH、C=O、 (其中 R3 为 H 或低级烷基）或单键；R1 为低级烷基、芳基、环烷基或 H，只有当 A 为单键时，R1 才可以是 H。
• US4977174A
  申请人：——

  公开号：US4977174A

  公开（公告）日：1990-12-11
• [EN] ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLD<br/>[FR] STRUCTURE MIMÉTIQUE D'HÉLICE ALPHA UTILISANT UN SQUELETTE 2,5-OLIGOPYRIMIDINE
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2010083501A2

  公开（公告）日：2010-07-22

  Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domain. The new scaffold is easier to make than previous scaffolds and has much more favorable physical properties than previous alpha-helix mimics. The amphiphilic alpha-helix mimetics have application for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.