4-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-phenyloxazole | 142075-59-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-phenyloxazole
• 英文别名: 4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-phenyl-oxazole；Tert-butyl-dimethyl-[2-(2-phenyl-1,3-oxazol-4-yl)ethoxy]silane
• CAS: 142075-59-0
• 化学式: C₁₇H₂₅NO₂Si
• 分子量: 303.476
• InChiKey: WCKTXXYKOOVLRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.91
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  35.26
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-phenyloxazole 在 oxygen 作用下， 以 甲醇 、 水 为溶剂， 以73%的产率得到N-(3-((tert-butyldimethylsilyl)oxy)propanoyl)-N-formylbenzamide
  参考文献：
  名称：

  2-phenyloxazolines as carboxylate precursors - applications to the synthesis of asymmetric branched-chain structures

  摘要：

  A synthetic approach to the title compounds is presented that features the asymmetric elaboration of a chiral, non-racemic oxazoline followed by a two-step oxidative ring cleavage of the heterocycle to a triamide for further transformation.

  DOI：

  10.1016/s0040-4039(00)79046-0
• 作为产物：
  描述：

  (S)-4-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-phenyl-4,5-dihydro-oxazole 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 以85%的产率得到4-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-phenyloxazole
  参考文献：
  名称：

  2-phenyloxazolines as carboxylate precursors - applications to the synthesis of asymmetric branched-chain structures

  摘要：

  A synthetic approach to the title compounds is presented that features the asymmetric elaboration of a chiral, non-racemic oxazoline followed by a two-step oxidative ring cleavage of the heterocycle to a triamide for further transformation.

  DOI：

  10.1016/s0040-4039(00)79046-0

文献信息

• [EN] DEUTERATED COMPOUNDS<br/>[FR] COMPOSÉS DEUTÉRÉS
  申请人：[en]ALEBUND PHARMACEUTICALS (HONG KONG) LIMITED

  公开号：WO2023016440A1

  公开（公告）日：2023-02-16

  Disclosed herein are compounds according to formula (I), the pharmaceutical composition comprising the same, and uses thereof.