(3-amino-6-bromo-pyrazin-2-yl)-phenyl-methanone | 180332-66-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-amino-6-bromo-pyrazin-2-yl)-phenyl-methanone
• 英文别名: (3-Amino-6-bromopyrazin-2-yl)-phenylmethanone
• CAS: 180332-66-5
• 化学式: C₁₁H₈BrN₃O
• 分子量: 278.108
• InChiKey: IINKSZGEYAQROV-UHFFFAOYSA-N

物化性质

• 沸点：
  461.6±45.0 °C(Predicted)
• 密度：
  1.612±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Bioluminescent Endoscopy Methods And Compounds
  申请人：Neff Philip T.

  公开号：US20090081129A1

  公开（公告）日：2009-03-26

  Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.

  生物发光内窥镜检查方法和化合物，其中通过注入、灌注、插管、注射或以其他方式给予含有生物发光物质或产生生物发光的琼脂素和琼脂酶混合物的溶液来检查解剖物体，其中使用由生物发光物质发出的生物发光的图像和信息构成物体的彩色或单色图像。演示了允许将生物发光溶液灌注到某些组织区域的程序，例如但不限于常见胆管、泌尿道、胃肠道、心血管系统和淋巴系统，其中这些结构可以在手术过程中方便地可视化，以避免对这些结构造成损伤。这些图像也可以与可见光图像结合。提供了使用生物发光检测癌细胞的方法。公开的首选实施例包括膜渗透性海葵素类似物。
• Organic compounds
  申请人：BRUCE Ian

  公开号：US20090239847A1

  公开（公告）日：2009-09-24

  The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R 1 , R 2 , Ar′, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.

  本发明涉及一种化合物，其化学式为(I)或其盐，适宜为药用可接受的盐，或其溶剂化合物，其中基团R1、R2、Ar′、A和Y在描述中有定义，以及该化合物在治疗炎症和过敏症状中的应用。
• Organic Compounds
  申请人：Bruce Ian

  公开号：US20120214800A1

  公开（公告）日：2012-08-23

  The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R 1 , R 2 , Ar′, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.

  本发明涉及公式(I)的化合物或其盐，适当地为药学上可接受的盐或其溶剂，其中组R1，R2，Ar′，A和Y在说明中定义，以及该化合物在治疗炎症和过敏症状中的组合物和用途。
• PYRAZINES
  申请人：KINGS COLLEGE LONDON

  公开号：EP0914318A1

  公开（公告）日：1999-05-12
• PYRIDINES AND PYRAZINES AS INHIBITORS OF PI3K
  申请人：Novartis AG

  公开号：EP2257529A2

  公开（公告）日：2010-12-08