4-(3-氟苯基)苯甲腈 | 893734-52-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(3-氟苯基)苯甲腈
• 英文名称: 4-(3-Fluorophenyl)benzonitrile
• CAS: 893734-52-6
• 化学式: C₁₃H₈FN
• mdl: MFCD05981077
• 分子量: 197.212
• InChiKey: UYVGIYZVAXQZQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

SDS

MSDS英文版

反应信息

• 作为产物：
  描述：

  4-溴苯腈 、 3-氟苯基硼酸 在 potassium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以95%的产率得到4-(3-氟苯基)苯甲腈
  参考文献：
  名称：

  Cellulose-supported N-heterocyclic carbene-palladium catalyst: Synthesis and its applications in the Suzuki cross-coupling reaction

  摘要：

  A cellulose-supported N-methylimidazole-palladium catalyst (Cell-NHC-Pd) was synthesized and used for Suzuki cross-coupling reactions between aryl halides and phenylboronic acids to create the corresponding coupling products in good to excellent yields. Moreover, the catalyst is easily recovered using only a few cycles of simple filtration.

  DOI：

  10.1016/j.carbpol.2014.08.030

文献信息

• Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：——

  公开号：US20020128292A1

  公开（公告）日：2002-09-12

  The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: 1 wherein X, Ar 1 , R 2 -R 6 and R 12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代的吲哚-2-羧酸亚苄基肼及其类似物，其由通式I表示： 1 其中X，Ar 1 ，R 2 -R 6 和R 12 的定义如本文中所述。本发明还涉及发现具有I式的化合物是半胱天冬酶的激活剂和凋亡的诱导剂。本发明的化合物可用于诱导在异常细胞不受控制的生长和扩散发生的多种临床状况中的细胞死亡。
• 10.1016/j.tet.2024.134052
  作者：Li, Zixu、Wang, Fei、Ma, Kai、Fang, Chao、Jia, Qiang、Chu, Changhu

  DOI：10.1016/j.tet.2024.134052

  日期：——

  could be used as an alternative substrate for Suzuki cross coupling. In this manuscript, a novel ppm-Pd-Fe/C catalyst has been developed by reduction of palladium acetate and iron trichloride with aqueous hydrazine in situ and supported on activated charcoal. In combined with Sphos, and metal zinc as additives, this catalyst, with 300 ppm palladium loading, could be applied in the Suzuki cross coupling

  芳基三氟甲磺酸酯是一种容易获得的化合物，可用作 Suzuki 交叉偶联的替代底物。在这篇手稿中，通过用肼水溶液原位还原乙酸钯和三氯化铁并负载在活性炭上，开发了一种新型 ppm-Pd-Fe/C 催化剂。与 Sphos 和金属锌作为添加剂相结合，该催化剂的钯负载量为 300 ppm，可应用于芳基三氟甲磺酸酯与芳基新戊基乙二醇硼酸酯之间的 Suzuki 交叉偶联。
• LIQUID CRYSTAL MATERIALS
  申请人：DOW CORNING CORPORATION

  公开号：EP1713880A1

  公开（公告）日：2006-10-25
• Liquid crystal materials
  申请人：Coles Harry

  公开号：US20090115957A1

  公开（公告）日：2009-05-07

  A blue phase liquid crystalline material comprising a mixture comprising at least one bimesogenic compound and at least one chiral compound, wherein the material is capable of stable existence in the blue phase over a temperature range of at least 5° C. A process for the preparation of the above blue phase liquid crystalline material, an optical device comprising it, a process of mirrorless lasing and a slotted monolithic optical waveguide using it are also disclosed.
• US6747052B2
  申请人：——

  公开号：US6747052B2

  公开（公告）日：2004-06-08