methyl 1-methyl-2-(2-aminophenyl)-1H-pyrrole-3-carboxylate | 1039340-65-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 1-methyl-2-(2-aminophenyl)-1H-pyrrole-3-carboxylate
• 英文别名: Methyl 2-(2-aminophenyl)-1-methylpyrrole-3-carboxylate；methyl 2-(2-aminophenyl)-1-methylpyrrole-3-carboxylate
• CAS: 1039340-65-2
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: LPYPHBODLMULHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 1-methyl-2-(2-aminophenyl)-1H-pyrrole-3-carboxylate 在 溶剂黄146 作用下， 以 仲丁醇 为溶剂， 反应 4.0h， 生成 1-methyl-1H-pyrrolo[3,2-c]quinolin-4(5H)-one
  参考文献：
  名称：

  Microwave-assisted multi-step synthesis of novel pyrrolo-[3,2-c]quinoline derivatives

  摘要：

  A new approach for the synthesis of original substituted pyrrolo-[3,2-c]quinoline derivatives using microwave-assisted chemistry is described. The use of microwave activation in this synthesis resulted in high yielding and clean steps. The key step for introducing diversity is the amination or the Pd-catalyzed cross-coupling of an imidoyl chloride derivative, obtained in a straightforward manner and in good yield. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.034
• 作为产物：
  描述：

  methyl 1-methyl-2-(2-nitrophenyl)-1H-pyrrole-3-carboxylate 在 palladium dihydroxide 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以98%的产率得到methyl 1-methyl-2-(2-aminophenyl)-1H-pyrrole-3-carboxylate
  参考文献：
  名称：

  Microwave-assisted multi-step synthesis of novel pyrrolo-[3,2-c]quinoline derivatives

  摘要：

  A new approach for the synthesis of original substituted pyrrolo-[3,2-c]quinoline derivatives using microwave-assisted chemistry is described. The use of microwave activation in this synthesis resulted in high yielding and clean steps. The key step for introducing diversity is the amination or the Pd-catalyzed cross-coupling of an imidoyl chloride derivative, obtained in a straightforward manner and in good yield. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.034

文献信息

• Microwave-assisted multi-step synthesis of novel pyrrolo-[3,2-c]quinoline derivatives
  作者：Hafid Benakki、Evelina Colacino、Christophe André、Farhate Guenoun、Jean Martinez、Frédéric Lamaty

  DOI：10.1016/j.tet.2008.04.034

  日期：2008.6

  A new approach for the synthesis of original substituted pyrrolo-[3,2-c]quinoline derivatives using microwave-assisted chemistry is described. The use of microwave activation in this synthesis resulted in high yielding and clean steps. The key step for introducing diversity is the amination or the Pd-catalyzed cross-coupling of an imidoyl chloride derivative, obtained in a straightforward manner and in good yield. (C) 2008 Elsevier Ltd. All rights reserved.