ethyl (2S,3S)-2-(3-chlorobenzoyl)-2-fluoro-3-(4-methylphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate | 1301669-32-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: ethyl (2S,3S)-2-(3-chlorobenzoyl)-2-fluoro-3-(4-methylphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 1301669-32-8
• 化学式: C₂₄H₂₇ClFNO₅
• 分子量: 463.933
• InChiKey: LAZQWQROPUMIJX-CYFREDJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 3-(3-chlorophenyl)-2-fluoro-3-oxopropanoate 、 4-methylbenzaldehyde N-(tert-butoxycarbonyl)imine 在 2BF₄^(1-)*C₄₆H₃₇NOP₂Pd⁽²⁺⁾ 作用下， 以 甲苯 为溶剂， 反应 7.0h， 生成 、 ethyl (2S,3S)-2-(3-chlorobenzoyl)-2-fluoro-3-(4-methylphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
  参考文献：
  名称：

  Catalytic asymmetric Mannich-type reactions of fluorinated ketoesters with N-Boc aldimines in the presence of chiral palladium complexes

  摘要：

  The catalytic enantioselective Mannich reaction promoted by chiral palladium complexes is described. The treatment of alpha-fluoro-beta-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding beta-aminated alpha-fluoro-beta-ketoesters with excellent enantioselectivities (up to 99% ee). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.087

文献信息

• Catalytic asymmetric Mannich-type reactions of fluorinated ketoesters with N-Boc aldimines in the presence of chiral palladium complexes
  作者：Young Ku Kang、Dae Young Kim

  DOI：10.1016/j.tetlet.2011.02.087

  日期：2011.5

  The catalytic enantioselective Mannich reaction promoted by chiral palladium complexes is described. The treatment of alpha-fluoro-beta-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding beta-aminated alpha-fluoro-beta-ketoesters with excellent enantioselectivities (up to 99% ee). (C) 2011 Elsevier Ltd. All rights reserved.