(3-(4-methoxyphenyl)-5-phenylpenta-1,4-diynyl)trimethylsilane | 1252883-20-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (3-(4-methoxyphenyl)-5-phenylpenta-1,4-diynyl)trimethylsilane
• 英文别名: [3-(4-Methoxyphenyl)-5-phenylpenta-1,4-diynyl]-trimethylsilane；[3-(4-methoxyphenyl)-5-phenylpenta-1,4-diynyl]-trimethylsilane
• CAS: 1252883-20-7
• 化学式: C₂₁H₂₂OSi
• 分子量: 318.491
• InChiKey: ZUCZEVILRINWLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.71
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙炔 、 1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.08h， 以84%的产率得到(3-(4-methoxyphenyl)-5-phenylpenta-1,4-diynyl)trimethylsilane
  参考文献：
  名称：

  Atom-Economical Chemoselective Synthesis of 1,4-Diynes and Polysubstituted Furans/Pyrroles from Propargyl Alcohols and Terminal Alkynes

  摘要：

  Under different conditions, the reaction of propargyl alcohols and terminal alkynes leads to the selective formation of 1,4-diynes and polysubstituted furans/pyrroles. Water is the only byproduct in the selective synthesis of 1,4-diynes and pyrroles, and the strategy for the furan synthesis is of 100% atom economy.

  DOI：

  10.1021/ol201054z

文献信息

• Solvent-free solid acid-catalyzed nucleophilic substitution of propargylic alcohols: a green approach for the synthesis of 1,4-diynes
  作者：Tao Wang、Rui-da Ma、Liu Liu、Zhuang-ping Zhan

  DOI：10.1039/c0gc00117a

  日期：——

  Acid-treated K10 montmorillonite (H-K10 mont) exhibited an outstanding catalytic activity in the nucleophilic substitution of propargylic alcohols with alkynylsilanes. The reactions were carried out under solvent-free conditions, and the solid catalyst was reusable with retention of its high activity. This method provides a green and rapid route to 1,4-diynes.

  酸处理的K10蒙脱石（H-K10 mont）在炔丙基的亲核取代中表现出出色的催化活性 酒类与炔基硅烷。反应在以下条件下进行溶剂无条件的情况下，固体 催化剂可重复使用，并保留其高活性。该方法提供了一条绿色且快速的途径来生产1,4-二炔。
• Atom-Economical Chemoselective Synthesis of 1,4-Diynes and Polysubstituted Furans/Pyrroles from Propargyl Alcohols and Terminal Alkynes
  作者：Tao Wang、Xin-liang Chen、Li Chen、Zhuang-ping Zhan

  DOI：10.1021/ol201054z

  日期：2011.7.1

  Under different conditions, the reaction of propargyl alcohols and terminal alkynes leads to the selective formation of 1,4-diynes and polysubstituted furans/pyrroles. Water is the only byproduct in the selective synthesis of 1,4-diynes and pyrroles, and the strategy for the furan synthesis is of 100% atom economy.