6-Phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-yn-1-ol | 192506-64-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 6-Phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-yn-1-ol
• CAS: 192506-64-2
• 化学式: C₄₀H₄₄O₇
• 分子量: 636.785
• InChiKey: KBFYRSWMZMRMJS-CSXXARLHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.32
• 重原子数：
  47.0
• 可旋转键数：
  16.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  75.61
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  6-Phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-yn-1-ol 在 4-二甲氨基吡啶 、 重铬酸吡啶 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  New glycosylation reaction based on alkyne-Co2(CO)6 complex

  摘要：

  O-Protected glycopyranoside possessing 4-(O-protected-glucosyl)-6-phenyl-5-hexynoate residue at anomeric position was converted into the corresponding cobalt complex, which on exposure to trimethylsilyl trifluoromethanesulfonate afforded glucosylglucoside derivative in a good yield via internal delivery of glycosyl acceptor. Similar O-protected galactopyranoside and mannopyranoside derivatives provided the corresponding galactosylglucoside and mannosylglucoside derivative, respectively. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00983-0
• 作为产物：
  描述：

  6-{[tert-Butyl(diphenyl)silyl]oxy}-1-phenylhex-1-yn-3-ol 在 dicobalt octacarbonyl 、 ammonium cerium(IV) nitrate 、 三氟化硼乙醚 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 6-Phenyl-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-hex-5-yn-1-ol
  参考文献：
  名称：

  New glycosylation reaction based on alkyne-Co2(CO)6 complex

  摘要：

  O-Protected glycopyranoside possessing 4-(O-protected-glucosyl)-6-phenyl-5-hexynoate residue at anomeric position was converted into the corresponding cobalt complex, which on exposure to trimethylsilyl trifluoromethanesulfonate afforded glucosylglucoside derivative in a good yield via internal delivery of glycosyl acceptor. Similar O-protected galactopyranoside and mannopyranoside derivatives provided the corresponding galactosylglucoside and mannosylglucoside derivative, respectively. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00983-0