4-((4-(1H-indazol-4-yl)-6-morpholino-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide | 1391924-81-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-((4-(1H-indazol-4-yl)-6-morpholino-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide
• 英文别名: 4-[[4-(1H-indazol-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]oxy]-N,N-dimethylbenzamide
• CAS: 1391924-81-4
• 化学式: C₂₃H₂₃N₇O₃
• 分子量: 445.481
• InChiKey: HOLZLKJUQNXYRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• US9481670B2
  申请人：——

  公开号：US9481670B2

  公开（公告）日：2016-11-01
• [EN] NOVEL TRIAZINE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE TRIAZINE
  申请人：SPHAERA PHARMA PRIVATE LTD

  公开号：WO2012101654A2

  公开（公告）日：2012-08-02

  The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/ or the mTOR pathway.