[4-(3,5-Dihydroxybenzoyl)oxy-3-[(3,5-dihydroxybenzoyl)oxymethyl]butyl] 3,5-dihydroxybenzoate | 702659-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(3,5-Dihydroxybenzoyl)oxy-3-[(3,5-dihydroxybenzoyl)oxymethyl]butyl] 3,5-dihydroxybenzoate
• 英文别名: [4-(3,5-dihydroxybenzoyl)oxy-3-[(3,5-dihydroxybenzoyl)oxymethyl]butyl] 3,5-dihydroxybenzoate
• CAS: 702659-39-0
• 化学式: C₂₆H₂₄O₁₂
• 分子量: 528.469
• InChiKey: DZQWXHGTNBKFDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  38
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  200
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  3,5-二苄氧基苯甲酸 、 [4-(3,5-Dihydroxybenzoyl)oxy-3-[(3,5-dihydroxybenzoyl)oxymethyl]butyl] 3,5-dihydroxybenzoate 在 N,N'-二环己基碳二亚胺 、 DPTS 作用下， 以 二氯甲烷 为溶剂， 反应 72.0h， 以69%的产率得到[3-[4-[3,5-Bis[[3,5-bis(phenylmethoxy)benzoyl]oxy]benzoyl]oxy-3-[[3,5-bis[[3,5-bis(phenylmethoxy)benzoyl]oxy]benzoyl]oxymethyl]butoxy]carbonyl-5-[3,5-bis(phenylmethoxy)benzoyl]oxyphenyl] 3,5-bis(phenylmethoxy)benzoate
  参考文献：
  名称：

  Synthesis of new unsymmetrical polyarylester dendrimers

  摘要：

  Preparation of polyarylester dendrimers containing 2-(hydroxymethyl)-1,4-butanediol and 2,2-bis(hydroxymethyl)-1,4-butanediol cores is described. These polyarylester dendrimers are unsymmetrical with respect to chain lengths and function as model systems for studying in vitro controlled drug release systems. Reaction conditions for deprotection of trichloroethyl group of the dendritic wedges have been improved. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.024
• 作为产物：
  描述：

  3,5-二羟基苯甲酸 在 palladium on activated charcoal sodium hydroxide 、 硫酸 、 氢气 、 potassium carbonate 、 N,N'-二环己基碳二亚胺 、 DPTS 作用下， 以 乙醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 32.0h， 生成 [4-(3,5-Dihydroxybenzoyl)oxy-3-[(3,5-dihydroxybenzoyl)oxymethyl]butyl] 3,5-dihydroxybenzoate
  参考文献：
  名称：

  Synthesis of new unsymmetrical polyarylester dendrimers

  摘要：

  Preparation of polyarylester dendrimers containing 2-(hydroxymethyl)-1,4-butanediol and 2,2-bis(hydroxymethyl)-1,4-butanediol cores is described. These polyarylester dendrimers are unsymmetrical with respect to chain lengths and function as model systems for studying in vitro controlled drug release systems. Reaction conditions for deprotection of trichloroethyl group of the dendritic wedges have been improved. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.024

文献信息

• Synthesis of new unsymmetrical polyarylester dendrimers
  作者：Srinagesh Kumar Potluri、A Raghu Ramulu、M Pardhasaradhi

  DOI：10.1016/j.tet.2004.03.024

  日期：2004.4

  Preparation of polyarylester dendrimers containing 2-(hydroxymethyl)-1,4-butanediol and 2,2-bis(hydroxymethyl)-1,4-butanediol cores is described. These polyarylester dendrimers are unsymmetrical with respect to chain lengths and function as model systems for studying in vitro controlled drug release systems. Reaction conditions for deprotection of trichloroethyl group of the dendritic wedges have been improved. (C) 2004 Elsevier Ltd. All rights reserved.