N-{9-[(4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl]-6-chloro-9H-purin-2-yl}-acetamide | 214279-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N-{9-[(4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl]-6-chloro-9H-purin-2-yl}-acetamide
• 英文别名: N-[9-[(4S,5R)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-phenylmethoxythiolan-3-yl]-6-chloropurin-2-yl]acetamide
• CAS: 214279-95-5
• 化学式: C₃₅H₃₈ClN₅O₃SSi
• 分子量: 672.323
• InChiKey: YIHQBIHELAUAJE-LRYYGPATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.26
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-{9-[(4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl]-6-chloro-9H-purin-2-yl}-acetamide 在 氟化铵 、 氢氟酸 、 氨 、 三氯化硼 作用下， 以 甲醇 、 ammonium hydroxide 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.5h， 生成 N-[6-Amino-9-((3S,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-thiophen-3-yl)-9H-purin-2-yl]-acetamide
  参考文献：
  名称：

  Synthesis of Novel Iso-4‘-thionucleosides Using the Mitsunobu Reaction

  摘要：

  A novel class of isomeric 4'-thionucleosides with the base moiety at the 2'-position was synthesized from D-glucose. The coupling of 1,4-anhydro-4-thioarabitol (13) with various nucleobases using the Mitsunobu reaction was investigated. With both purines and N-3-benzoyluracils, the reaction predominantly gave beta-isomers, suggesting that these were produced via an episulfonium intermediate. The beta-anomers produced by the reaction of N-3-benzoyluracils included both N- and O-alkylated derivatives. Interestingly, only the reaction of N-3-benzoyluracil gave a mixture of N-alkylated adduct (20d) and O-alkylated bipyrimidinyl adduct (22), the structure of which was unambiguously determined by NMR spectroscopic data including HMBC and NOE. Deprotection of the Mitsunobu reaction products gave the desired iso-4'-thionucleosides.

  DOI：

  10.1021/jo980667s
• 作为产物：
  描述：

  N-(6-氯-9h-嘌呤-2-基)乙酰胺 、 (3S,4S,5R)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-phenylmethoxythiolan-3-ol 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以38%的产率得到N-{9-[(4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl]-6-chloro-9H-purin-2-yl}-acetamide
  参考文献：
  名称：

  Synthesis of Novel Iso-4‘-thionucleosides Using the Mitsunobu Reaction

  摘要：

  A novel class of isomeric 4'-thionucleosides with the base moiety at the 2'-position was synthesized from D-glucose. The coupling of 1,4-anhydro-4-thioarabitol (13) with various nucleobases using the Mitsunobu reaction was investigated. With both purines and N-3-benzoyluracils, the reaction predominantly gave beta-isomers, suggesting that these were produced via an episulfonium intermediate. The beta-anomers produced by the reaction of N-3-benzoyluracils included both N- and O-alkylated derivatives. Interestingly, only the reaction of N-3-benzoyluracil gave a mixture of N-alkylated adduct (20d) and O-alkylated bipyrimidinyl adduct (22), the structure of which was unambiguously determined by NMR spectroscopic data including HMBC and NOE. Deprotection of the Mitsunobu reaction products gave the desired iso-4'-thionucleosides.

  DOI：

  10.1021/jo980667s