3-(2-Hydroxy-phenylamino)-1-(3-nitro-phenyl)-propan-1-one | 36946-00-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-Hydroxy-phenylamino)-1-(3-nitro-phenyl)-propan-1-one
• 英文别名: 3-[(2-Hydroxyphenyl)amino]-1-(3-nitrophenyl)propan-1-one；3-(2-hydroxyanilino)-1-(3-nitrophenyl)propan-1-one
• CAS: 36946-00-6
• 化学式: C₁₅H₁₄N₂O₄
• 分子量: 286.287
• InChiKey: MWGSGJAXSRCPEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compositions and methods for the treatment of disease associated with Trp-p8 expression
  申请人：Natarajan K. Sateesh

  公开号：US20050054651A1

  公开（公告）日：2005-03-10

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物，以及用于识别和表征新型小分子Trp-p8调节剂的方法，以及用于降低Trp-p8表达细胞的存活能力和/或抑制生长的方法，用于激活Trp-p8介导的阳离子流入的方法，用于刺激凋亡和/或坏死的方法，以及用于治疗疾病的相关方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与Trp-p8表达相关的其他疾病，如良性前列腺增生。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION
  申请人：Natarajan Sateesh K.

  公开号：US20120094977A1

  公开（公告）日：2012-04-19

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物，以及用于识别和表征新型小分子Trp-p8调节剂的方法，以及用于降低Trp-p8表达细胞的存活率和/或抑制生长的方法，用于激活Trp-p8介导的阳离子流入的方法，用于刺激凋亡和/或坏死的方法，以及相关的治疗疾病的方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与Trp-p8表达相关的其他疾病，例如良性前列腺增生等。
• 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for gastrointestinal dysfunction
  申请人：——

  公开号：US20030206873A1

  公开（公告）日：2003-11-06

  A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one sensory nerve receptor agonist in a therapeutically effective amount. The sensory nerve receptor agonist may be represented by the general formula 1-[R1-phenyl]-4-[R2-phenyl]-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 may be -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl ; and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions of the invention reduce pain, a sense of abdominal distension, tenesmus, and abnormal bowel function when formulated for oral delivery to human gastrointestinal tract and are useful to alleviate gastrointestinal dysfunction.

  提供了一种治疗组合物，它包含治疗有效量的 1-R1-苯基、4-R2-苯基取代的 1，2，3，6-四氢嘧啶-2-酮感觉神经受体激动剂。感觉神经受体激动剂可由通式 1-[R1-苯基]-4-[R2-苯基]-1,2,3,6-四氢嘧啶-2-酮表示 其中：R1可以是-羟基、-氯、-氟、-烷基、-乙酰氧基、-三氟甲基；R2是-硝基、-氯、-氟、-烷基、-三氟甲基。本发明的治疗组合物在配制成口服给药到人体胃肠道时，可减轻疼痛、腹胀感、胀气和肠道功能异常，有助于缓解胃肠功能紊乱。
• 1,2,3,6-tetrahydropyrimidine-2-one compositions and therapeutic methods therewith for pain and inflammation
  申请人：——

  公开号：US20030207904A1

  公开（公告）日：2003-11-06

  A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one sensory nerve receptor agonist in a therapeutically effective amount. The sensory nerve receptor agonist may be represented by the general formula 1-[R1-phenyl]-4-[R2-phenyl]-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 is -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl; and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions of the invention reduce pain, itch, and a sense of discomfort, when formulated for topical delivery to the human lips, mouth, and to the anorectal area.

  提供了一种治疗组合物，它包含治疗有效量的 1-R1-苯基、4-R2-苯基取代的 1，2，3，6-四氢嘧啶-2-酮感觉神经受体激动剂。感觉神经受体激动剂可由通式 1-[R1-苯基]-4-[R2-苯基]-1,2,3,6-四氢嘧啶-2-酮表示 其中：R1为-羟基、-氯、-氟、-烷基、-乙酰氧基、-三氟甲基；R2为-硝基、-氯、-氟、-烷基、-三氟甲基。本发明的治疗组合物在配制成局部给药时，可减轻人体嘴唇、口腔和肛门直肠部位的疼痛、瘙痒和不适感。
• EP1663962A4
  申请人：——

  公开号：EP1663962A4

  公开（公告）日：2007-08-22