[Pt2(N,N'-bis(2-dimethylaminoethyl oxamide)Cl4] | 296763-30-9

• 英文名称: [Pt2(N,N'-bis(2-dimethylaminoethyl oxamide)Cl4]
• CAS: 296763-30-9；606934-60-5
• 化学式: C₁₀H₂₀Cl₄N₄O₂Pt₂
• 分子量: 760.266
• InChiKey: LBINNVPAYVBNFA-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 N,N'-bis<2-(dimethylamino)ethyl>oxamide 以 水 为溶剂， 生成 [Pt2(N,N'-bis(2-dimethylaminoethyl oxamide)Cl4]
  参考文献：
  名称：

  Structural Features of a New Dinuclear Platinum(II) Complex with Significant Antiproliferative Activity

  摘要：

  A novel dinuclear platinum(II) complex, [Pt-2-N, N'-bis(2-dimethylaminoethyl oxamide)Cl-4], showing peculiar structural features, has been prepared and characterized. X-ray diffraction data reveal that the two platinum ions are simultaneously bound to the N,N'-bis-(2-dimethylaminoethyl) oxamide ligand, on opposite sides. The coordination environment of both platinum centers is square planar, with identical NOCl2 donor sets. The complex is poorly soluble within a physiological buffer but moderately soluble in DMSO. Preliminary in vitro studies point out that this dinuclear platinum complex exhibits significant growth-inhibiting properties on a panel of cultured human tumor cell lines, although less pronounced than those of cisplatin.

  DOI：

  10.1021/ic034025l