(S^*,R^*)-N-Allyl-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-(methoxymethoxy)-3-nonylamine | 137967-34-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S^*,R^*)-N-Allyl-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-(methoxymethoxy)-3-nonylamine
• 英文别名: (2S,3R)-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-(methoxymethoxy)-N-prop-2-enylnonan-3-amine
• CAS: 137967-34-1
• 化学式: C₁₄H₁₆F₁₃NO₂
• 分子量: 477.266
• InChiKey: QPAAEGFUAPCSHX-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  全氟己基碘烷 、 2-丙烯-1-胺,N-[2-(甲氧基甲氧基)亚丙基]- 在 三氟化硼乙醚 、 甲基锂 、 lithium bromide 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 (S^*,R^*)-N-Allyl-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-(methoxymethoxy)-3-nonylamine 、 (S*,S*)-N-Allyl-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-(methoxymethoxy)-3-nonylamine
  参考文献：
  名称：

  Boron trifluoride-assisted perfluoroalkylation of carbon-nitrogen double bonds

  摘要：

  In the presence of BF3.OEt2, (perfluoroalkyl)lithiums generated in situ from the reaction of primary perfluoroalkyl iodides and MeLi-LiBr reacted with imines, azines, and nitrones to afford perfluoroalkylated nitrogen-containing compounds in moderate to good yields. This method was successfully applied to the preparation of a (perfluoroalkyl)glycine and optically active perfluoroalkylated amines.

  DOI：

  10.1021/jo00031a032

文献信息

• Boron trifluoride-assisted perfluoroalkylation of carbon-nitrogen double bonds
  作者：Hidemitsu Uno、Shinichiro Okada、Tetsushi Ono、Yasukazu Shiraishi、Hitomi Suzuki

  DOI：10.1021/jo00031a032

  日期：1992.2

  In the presence of BF3.OEt2, (perfluoroalkyl)lithiums generated in situ from the reaction of primary perfluoroalkyl iodides and MeLi-LiBr reacted with imines, azines, and nitrones to afford perfluoroalkylated nitrogen-containing compounds in moderate to good yields. This method was successfully applied to the preparation of a (perfluoroalkyl)glycine and optically active perfluoroalkylated amines.