4-{4-[4-(5-benzoyl-1H-benzo[d]imidazol-2-ylcarbamoyl)-thiazol-2-yl]-piperidin-1-yl}-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester | 950675-04-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-{4-[4-(5-benzoyl-1H-benzo[d]imidazol-2-ylcarbamoyl)-thiazol-2-yl]-piperidin-1-yl}-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester
• 英文别名: methyl 4-(4-(4-(5-benzoyl-1H-benzo[d]imidazol-2-ylcarbamoyl)thiazol-2-yl)piperidin-1-yl)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate；methyl 4-[4-[4-[(6-benzoyl-1H-benzimidazol-2-yl)carbamoyl]-1,3-thiazol-2-yl]piperidin-1-yl]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
• CAS: 950675-04-4
• 化学式: C₃₂H₂₈N₈O₄S
• 分子量: 620.692
• InChiKey: KQGVMKHXIWUREM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  176
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE
  申请人：STROBL Stefan

  公开号：US20080241100A1

  公开（公告）日：2008-10-02

  The present invention relates to a pharmaceutical composition comprising, (i) a cytokine and, (ii) a compound of the general formula (Ih) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof. Exemplary cytokines are selected from the following group of cytokine families, (i) the four α-helix bundle family, which consists of, (a) the IL-2 subfamily, (b) the interferon (IFN) subfamily and, (c) the IL-10 subfamily, (ii) the IL-1 family, (iii) the IL-17 family and, (iv) chemokines.

  本发明涉及一种药物组合物，包括（i）细胞因子和（ii）一般式（Ih）的化合物或其酸或碱的药学可接受盐，或药学可接受的前药或其立体异构体。示例细胞因子选择自以下细胞因子家族中的一组，（i）四α螺旋束家族，包括（a）IL-2亚家族，（b）干扰素（IFN）亚家族和（c）IL-10亚家族，（ii）IL-1家族，（iii）IL-17家族和（iv）趋化因子。
• Pharmaceutical composition comprising a cytokine
  申请人：Strobl Stefan

  公开号：US20110052532A1

  公开（公告）日：2011-03-03

  The present invention relates to a pharmaceutical composition comprising, (i) a cytokine and, (ii) a compound of the general formula (Ih) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof. Exemplary cytokines are selected from the following group of cytokine families, (i) the four α-helix bundle family, which consists of, (a) the IL-2 subfamily, (b) the interferon (IFN) subfamily and, (c) the IL-10 subfamily, (ii) the IL-1 family, (iii) the IL-17 family and, (iv) chemokines.

  本发明涉及一种药物组合物，包括（i）一种细胞因子和（ii）一种通式（Ih）化合物或其在酸或碱的存在下的药学上可接受的盐，或其药学上可接受的前药或其立体异构体。示例细胞因子选自以下细胞因子家族：（i）四α螺旋束家族，包括(a) IL-2亚家族，(b) 干扰素（IFN）亚家族和(c) IL-10亚家族，（ii）IL-1家族，（iii）IL-17家族和（iv）趋化因子。