4-hydroxy-2,6-diacetylpyridine | 119222-95-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-hydroxy-2,6-diacetylpyridine
• 英文别名: 2,6-diacetyl-1H-pyridin-4-one
• CAS: 119222-95-6
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: FVPHNIYDLNHZOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS
  申请人：HANSON Gunnar

  公开号：US20090104151A1

  公开（公告）日：2009-04-23

  The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

  本发明提供了Smac肽的小分子模拟物，这些模拟物是二聚体或三聚体化合物，具有由连接剂连接的两个或三个含酰胺的结构域。这些化合物对促进细胞凋亡很有用。本发明还包括包含这些化合物的药物组成物和使用它们治疗包括癌症和自身免疫性疾病在内的疾病的方法。
• Smac mimetic dimers and trimers useful as anti-cancer agents
  申请人：Joyant Pharmaceuticals, Inc.

  公开号：US20140127155A1

  公开（公告）日：2014-05-08

  The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

  这项发明提供了Smac肽的小分子类似物，它们是二聚体或三聚体化合物，具有由连接剂连接的两个或三个含酰胺的结构域。这些化合物有助于促进细胞凋亡。该发明包括包含这些化合物的药物组合物和使用它们治疗癌症和自身免疫性疾病等病症的方法。
• Grafting of transition metal complexes on supports
  申请人：TOTAL PETROCHEMICALS RESEARCH FELUY

  公开号：EP1559728A1

  公开（公告）日：2005-08-03

  The present invention discloses a method for supporting a transition metal complex and the resulting supported catalyst component which is characterised in that the metallic sites are kept away from one another and kept away from the surface of the support.

  本发明公开了一种用于支撑过渡金属络合物和由此产生的支撑催化剂组分的方法，其特征在于金属位点彼此远离，并远离支撑物表面。
• GRAFTING OF TRANSITION METAL COMPLEXES ON SUPPORTS.
  申请人：TOTAL PETROCHEMICALS RESEARCH FELUY

  公开号：EP1718684A1

  公开（公告）日：2006-11-08
• FE(II) SEQUESTERING AGENTS AND USES THEREOF
  申请人：Morrow Janet

  公开号：US20140072517A1

  公开（公告）日：2014-03-13

  Compounds and uses of the compounds are provided. The compounds can be used as Fe(II) sequestering compounds. For example, these compounds can be used to sequester Fe(II) in cells, organs, vasculature, or tissues. Also, provided are compositions and methods of using the them for sequestering Fe(II) in an individual. The compounds can be used as MRI paraCEST contrast agents.