1-[5-tert-Butyl-2-(1H-pyrazol-4-yl)-phenyl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | 1102203-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[5-tert-Butyl-2-(1H-pyrazol-4-yl)-phenyl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
• 英文别名: 1-[5-tert-butyl-2-(1H-pyrazol-4-yl)phenyl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
• CAS: 1102203-27-9
• 化学式: C₃₀H₃₅N₅O₃
• 分子量: 513.64
• InChiKey: HXNARSOBTYIVTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  91.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods of treating cytokine mediated diseases
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030060455A1

  公开（公告）日：2003-03-27

  Disclosed are methods of treating acute and chronic inflammation in the lung caused by inhalation of smoke, endometriosis, Behcet's disease, uveitis, ankylosing spondylitis, pancreatitis, cancer, Lyme disease, sepsis, chronic obstructive pulmonary disease, traumatic arthritis, congestive heart failure and restenosis following percutaneous transluminal coronary angioplasty, known to be cytokine mediated, using aromatic heterocyclic compounds described in WO 00/55139.

  本发明涉及使用在WO 00/55139中描述的芳香族杂环化合物治疗由吸入烟雾、子宫内膜异位症、Behcet病、葡萄膜炎、强直性脊柱炎、胰腺炎、癌症、莱姆病、败血症、慢性阻塞性肺疾病、创伤性关节炎、充血性心力衰竭和经皮冠状动脉成形术后再狭窄等已知为细胞因子介导的急性和慢性肺部炎症治疗的方法。
• Intermediate arylamine compounds
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030225077A1

  公开（公告）日：2003-12-04

  Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes of making such compounds.

  本发明涉及一种新型芳香化合物，可用于治疗涉及炎症的疾病或病理状况，如慢性炎症性疾病。还公开了含有该化合物的制药组合物、中间体化合物和制备该化合物的过程。
• Compounds useful as anti-inflammatory agents
  申请人：——

  公开号：US20020055507A1

  公开（公告）日：2002-05-09

  Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.

  本发明揭示了一种新型芳香化合物，其可用于治疗涉及炎症的疾病或病理状况，如慢性炎症性疾病。还揭示了含有这种化合物的制药组合物以及制备这种化合物的过程。
• Heterocyclic urea and related compounds useful as anti-inflammatory agents
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1466906A1

  公开（公告）日：2004-10-13

  Disclosed are novel aromatic compounds which are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

  所公开的新型芳香族化合物可用于治疗涉及炎症（如慢性炎症性疾病）的疾病或病理状况的药物组合物中。还公开了制造此类化合物的工艺。
• METHODS OF TREATING CYTOKINE MEDIATED DISEASES
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1427412A1

  公开（公告）日：2004-06-16