1-methyl-7-phenoxy-1,2,3,4-tetrahydronaphthalene | 1350704-34-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-methyl-7-phenoxy-1,2,3,4-tetrahydronaphthalene
• 英文别名: 1-Methyl-7-phenoxy-1,2,3,4-tetrahydronaphthalene
• CAS: 1350704-34-5
• 化学式: C₁₇H₁₈O
• 分子量: 238.329
• InChiKey: TXUFBBVXMAFNQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(4-苯氧基苯基)-1,4-戊二酮 在 三乙基硅烷 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以93%的产率得到1-methyl-7-phenoxy-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  A facile preparation of tetralins from arene-1,4-diones using titanium(IV) chloride and triethylsilane

  摘要：

  A facile method for the synthesis of tetralins has been described which uses various substituted phenylpentane-1,4-diones as starting material with a combination of TiCl4/Et3SiH. The synthesis involves three reactions under mild conditions. A mechanism has been proposed for the reductive cyclization through ionic hydrogenation, and titanium(IV) chloride catalyzed cyclization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.054

文献信息

• [EN] PEPTIDOMIMETICS AND METHODS OF USING THE SAME<br/>[FR] PEPTIDOMIMÉTIQUES ET SES PROCÉDÉS D'UTILISATION
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2018053240A1

  公开（公告）日：2018-03-22

  Disclosed herein are compounds useful for modulating the mu-opioid receptor ("MOR") and/or delta-opioid receptor ("DOR"), and methods of using these compounds to treat diseases and conditions, such as pain. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: (I), wherein the substituents are as described.
• A facile preparation of tetralins from arene-1,4-diones using titanium(IV) chloride and triethylsilane
  作者：Gang Li、Qiong Xiao、Chun Li、Xiaojian Wang、Dali Yin

  DOI：10.1016/j.tetlet.2011.10.054

  日期：2011.12

  A facile method for the synthesis of tetralins has been described which uses various substituted phenylpentane-1,4-diones as starting material with a combination of TiCl4/Et3SiH. The synthesis involves three reactions under mild conditions. A mechanism has been proposed for the reductive cyclization through ionic hydrogenation, and titanium(IV) chloride catalyzed cyclization. (C) 2011 Elsevier Ltd. All rights reserved.