1-(3,4,5-三甲氧基苄基)哌嗪二盐酸盐 | 107049-57-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(3,4,5-三甲氧基苄基)哌嗪二盐酸盐
• 英文名称: 1-(3,4,5-Trimethoxy-benzyl)-piperazine dihydrochloride
• 英文别名: 1-[(3,4,5-trimethoxyphenyl)methyl]piperazine;dihydrochloride
• CAS: 107049-57-0
• 化学式: C14H24Cl2N2O3
• 分子量: 339.3
• InChiKey: XIRALXKCBGTYSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  43
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  1-(3,4,5-三甲氧基苄基)哌嗪二盐酸盐 、 3-氯-1-(3,4-二氯苯)-1-丙酮 生成 1-(3,4-dichlorophenyl)-3-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]propan-1-one;dihydrochloride
  参考文献：
  名称：

  OHTAKA, HIROSHI;FUJIMOTO, YOSHIAKI;YOSHIDA, KENJI;KANAZAWA, TOSHIRO;ITO, +, CHEM. AND PHARM. BULL., 35,(1987) N 7, 2782-2791

  摘要：

  DOI：
• 作为产物：
  描述：

  哌嗪 、 3,4,5-三甲氧基苄氯 生成 1-(3,4,5-三甲氧基苄基)哌嗪二盐酸盐
  参考文献：
  名称：

  OHTAKA, HIROSHI;FUJIMOTO, YOSHIAKI;YOSHIDA, KENJI;KANAZAWA, TOSHIRO;ITO, +, CHEM. AND PHARM. BULL., 35,(1987) N 7, 2782-2791

  摘要：

  DOI：

文献信息

• Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent
  申请人：Li Jianqi

  公开号：US20060148811A1

  公开（公告）日：2006-07-06

  Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also dislcosed are methods for using the compounds as analgesic and sedative agents. The compounds of the present invention have good analgesic and sedative activities but few side effects.

  Arylalkyl酮哌嗪衍生物的公式为： 以及包含该化合物的药物组合物。还公开了将化合物用作镇痛和镇静剂的方法。本发明的化合物具有良好的镇痛和镇静活性，但副作用很少。
• PAF antagonist, 1,4-disubstituted piperazine compounds and production
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04937246A1

  公开（公告）日：1990-06-26

  Platelet Activating Factor (PAF) antagonists which comprise the compounds of the formula (I): ##STR1## wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R.sup.1, R.sup.2 and R.sup.3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal. Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4-yl group are novel compounds and exhibit excellent PAF antagonism.

  血小板活化因子（PAF）拮抗剂包括式（I）的化合物：##STR1## 其中A是可选取的取代苯基或可选取的取代杂环基；X是亚甲基、羰基或硫代羰基；R.sup.1、R.sup.2和R.sup.3是独立的低碳基，其盐在肠道中的吸收性能极佳。在式（I）的化合物中，其中A是可选取的取代2,3-二氢-1-苯并氧杂-4-基基团的新化合物，表现出优异的PAF拮抗作用。
• Piperazine compounds and anti-ulcer composition containing the same
  申请人：Kanebo, Ltd.

  公开号：US04797400A1

  公开（公告）日：1989-01-10

  Novel piperazine compounds of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is methoxy group and another is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof, which have excellent anti-peptic ulcer activities with potent activity for promoting the action of the defensive factor, and hence are useful as an anti-ulcer agent for the prophylaxis and treatment of peptic ulcers.

  该专利涉及一种新型哌嗪化合物，其化学式为：##STR1## 其中R.sup.1和R.sup.2中有一个为甲氧基基团，另一个为氢原子，或其药学上可接受的酸盐，该化合物具有出色的抗消化性溃疡活性，对促进防御因子的作用具有强效活性，因此可用作预防和治疗消化性溃疡的抗溃疡剂。
• 1,4-disubstituted piperazines (or homopiperazines) as
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04880809A1

  公开（公告）日：1989-11-14

  Novel 1,4-disubstituted piperazine compounds represented by the formula (I): ##STR1## wherein A is a condensed polycyclic hydrocarbon group; R is a phenyl group substituted with a lower alkoxy group; X is methylene group, carbonyl group or thiocarbonyl group; and m is 2 or 3, and their salts are useful as a platelet activating factor antagonist.

  化合物1,4-二取代哌嗪化合物，其化学式表示为(I): ##STR1## 其中，A为紧缩的多环碳氢基团；R为取代有较低烷氧基的苯基团；X为亚甲基基团、羰基基团或硫代羰基基团；m为2或3，它们的盐在抗血小板激活因子拮抗剂方面有用。
• 1,4-Disubstituted piperazine compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0284359A1

  公开（公告）日：1988-09-28

  Novel 1,4-disubstituted piperazine compounds represented by the formula (I): wherein A is a condensed polycyclic hydrocarbon group;     R is a phenyl group substituted with a lower alkoxy group;     X is methylene group, carbonyl group or thiocarbonyl group;     and m is 2 or 3, and their salts are useful as a platelet activating factor antagonist.

  由式(I)代表的新型1,4-二取代哌嗪化合物： 其中 A 是缩合多环烃基团 R 是被低级烷氧基取代的苯基 X 是亚甲基、羰基或硫代羰基； m 为 2 或 3，以及它们的盐类 可用作血小板活化因子拮抗剂。